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Target
Proto-oncogene tyrosine-protein kinase Src
Ligand
BDBM50064348
Substrate
n/a
Meas. Tech.
ChEMBL_216860 (CHEMBL816697)
IC50
>50000±n/a nM
Citation
 Trumpp-Kallmeyer, S; Rubin, JR; Humblet, C; Hamby, JM; Hollis Showalter, HD Development of a binding model to protein tyrosine kinases for substituted pyrido[2,3-d]pyrimidine inhibitors. J Med Chem 41:1752-63 (1998) [PubMed]  Article 
Target
Name:
Proto-oncogene tyrosine-protein kinase Src
Synonyms:
Proto-oncogene c-Src | SRC | SRC_CHICK | Tyrosine-protein kinase SRC | c-Src | p60-Src | p60c-src | pp60c-src
Type:
Tyr protein kinase
Mol. Mass.:
60015.36
Organism:
Gallus gallus (Chicken)
Description:
P00523
Residue:
533
Sequence:
MGSSKSKPKDPSQRRRSLEPPDSTHHGGFPASQTPNKTAAPDTHRTPSRSFGTVATEPKLFGGFNTSDTVTSPQRAGALAGGVTTFVALYDYESRTETDLSFKKGERLQIVNNTEGDWWLAHSLTTGQTGYIPSNYVAPSDSIQAEEWYFGKITRRESERLLLNPENPRGTFLVRESETTKGAYCLSVSDFDNAKGLNVKHYKIRKLDSGGFYITSRTQFSSLQQLVAYYSKHADGLCHRLTNVCPTSKPQTQGLAKDAWEIPRESLRLEVKLGQGCFGEVWMGTWNGTTRVAIKTLKPGTMSPEAFLQEAQVMKKLRHEKLVQLYAVVSEEPIYIVTEYMSKGSLLDFLKGEMGKYLRLPQLVDMAAQIASGMAYVERMNYVHRDLRAANILVGENLVCKVADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYGRFTIKSDVWSFGILLTELTTKGRVPYPGMVNREVLDQVERGYRMPCPPECPESLHDLMCQCWRKDPEERPTFEYLQAFLEDYFTSTEPQYQPGENL
  
Inhibitor
Name:
BDBM50064348
Synonyms:
2-Amino-6-(3,5-dimethoxy-phenyl)-8-methyl-8H-pyrido[2,3-d]pyrimidin-7-one | 2-amino-6-(3,5-dimethoxyphenyl)-8-methylpyrido[2,3-d]pyrimidin-7(8H)-one | CHEMBL296540
Type:
Small organic molecule
Emp. Form.:
C16H16N4O3
Mol. Mass.:
312.3232
SMILES:
COc1cc(OC)cc(c1)-c1cc2cnc(N)nc2n(C)c1=O
Structure:
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