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Target
Polyunsaturated fatty acid 5-lipoxygenase
Ligand
BDBM50029775
Substrate
n/a
Meas. Tech.
ChEMBL_3888 (CHEMBL619403)
IC50
298±n/a nM
Citation
 Cai, X; Scannell, RT; Yaeger, D; Hussoin, MS; Killian, DB; Qian, C; Eckman, J; Hwang, SB; Libertine-Garahan, L; Yeh, CG; Ip, SH; Shen, TY (+/-)-trans-2-[3-methoxy-4-(4-chlorophenylthioethoxy)-5-(N-methyl-N- hydroxyureidyl)methylphenyl]-5-(3,4, 5-trimethoxyphenyl)tetrahydrofuran (CMI-392), a potent dual 5-lipoxygenase inhibitor and platelet-activating factor receptor antagonist. J Med Chem 41:1970-9 (1998) [PubMed]  Article 
Target
Name:
Polyunsaturated fatty acid 5-lipoxygenase
Synonyms:
Alox5 | Arachidonate 5-lipoxygenase | LOX5_RAT
Type:
PROTEIN
Mol. Mass.:
78082.31
Organism:
Rattus norvegicus
Description:
ChEMBL_1432947
Residue:
673
Sequence:
MPSYTVTVATGSQWFAGTDDYIYLSLIGSAGCSEKHLLDKAFYNDFERGGRDSYDVTVDEELGEIYLVKIEKRKYRLHDDWYLKYITLKTPHDYIEFPCYRWITGEGEIVLRDGCAKLARDDQIHILKQHRRKELETRQKQYRWMEWNPGFPLSIDAKCHKDLPRDIQFDSEKGVDFVLNYSKAMENLFINRFMHMFQSSWHDFADFEKIFVKISNTISERVKNHWQEDLMFGYQFLNGCNPVLIKRCTELPKKLPVTTEMVECSLERQLSLEQEVQEGNIFIVDYELLDGIDANKTDPCTHQFLAAPICLLYKNLANKIVPIAIQLNQTPGEKNPIFLPTDSKYDWLLAKIWVRSSDFHIHQTITHLLRTHLVSEVFGIAMYRQLPAVHPLFKLLVAHVRFTIAINTKAREQLNCEYGLFDKANATGGGGHVQMVQRAVQDLTYSSLCFPEAIKARGMDNTEDIPYYFYRDDGLLVWEAIQSFTTEVVSIYYEDDQVVEEDQELQDFVKDVYVYGMRGRKASGFPKSIKSREKLSEYLTVVIFTASAQHAAVNFGQYDWCSWIPNAPPTMRAPPPTAKGVVTIEQIVDTLPDRGRSCWHLGAVWALSQFQENELFLGMYPEEHFIEKPVKEAMIRFRKNLEAIVSVIAERNKNKKLPYYYLSPDRIPNSVAI
  
Inhibitor
Name:
BDBM50029775
Synonyms:
(R)-(+)-N-{3-[5-(4-fluorophenoxy)furan-2-yl]-1-methylprop-2-ynyl}-N-hydroxyurea | (S)-(-)-N-{3-[5-(4-fluorophenoxy)furan-2-yl]-1-methylprop-2-ynyl}-N-hydroxyurea | A-78773 | CHEMBL59598 | N-{3-[5-(4-fluorophenoxy)-2-furyl]-1-methylprop-2-ynyl}-N-hydroxyurea | N-{3-[5-(4-fluorophenoxy)-2-furyl]-1-methylprop-2-ynyl}-N-hydroxyurea(A-78773) | N-{3-[5-(4-fluorophenoxy)furan-2-yl]-1-methylprop-2-ynyl}-N-hydroxyurea
Type:
Small organic molecule
Emp. Form.:
C15H13FN2O4
Mol. Mass.:
304.2731
SMILES:
CC(C#Cc1ccc(Oc2ccc(F)cc2)o1)N(O)C(N)=O
Structure:
Search PDB for entries with ligand similarity: