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Target
Taste receptor type 2 member 14
Ligand
BDBM211262
Substrate
n/a
Meas. Tech.
ChEMBL_1846017 (CHEMBL4346444)
EC50
40000±n/a nM
Citation
 Fotsing, JR; Darmohusodo, V; Patron, AP; Ching, BW; Brady, T; Arellano, M; Chen, Q; Davis, TJ; Liu, H; Servant, G; Zhang, L; Williams, M; Saganich, M; Ditschun, T; Tachdjian, C; Karanewsky, DS Discovery and Development of S6821 and S7958 as Potent TAS2R8 Antagonists. J Med Chem 63:4957-4977 (2020) [PubMed]  Article 
Target
Name:
Taste receptor type 2 member 14
Synonyms:
T2R14 | T2R14_HUMAN | TAS2R14 | TRB1 | Taste receptor family B member 1
Type:
n/a
Mol. Mass.:
36183.39
Organism:
Homo sapiens (Human)
Description:
Q9NYV8
Residue:
317
Sequence:
MGGVIKSIFTFVLIVEFIIGNLGNSFIALVNCIDWVKGRKISSVDRILTALAISRISLVWLIFGSWCVSVFFPALFATEKMFRMLTNIWTVINHFSVWLATGLGTFYFLKIANFSNSIFLYLKWRVKKVVLVLLLVTSVFLFLNIALINIHINASINGYRRNKTCSSDSSNFTRFSSLIVLTSTVFIFIPFTLSLAMFLLLIFSMWKHRKKMQHTVKISGDASTKAHRGVKSVITFFLLYAIFSLSFFISVWTSERLEENLIILSQVMGMAYPSCHSCVLILGNKKLRQASLSVLLWLRYMFKDGEPSGHKEFRESS
  
Inhibitor
Name:
BDBM211262
Synonyms:
US9247759, 10-10
Type:
Small organic molecule
Emp. Form.:
C19H19N5O4
Mol. Mass.:
381.3853
SMILES:
Cc1noc(C)c1Cn1cc(cn1)N1C(=O)CN(Cc2cccc(O)c2)C1=O
Structure:
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