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Target
Alpha-1B adrenergic receptor
Ligand
BDBM50409811
Substrate
n/a
Meas. Tech.
ChEMBL_1852732 (CHEMBL4353356)
Ki
47±n/a nM
Citation
 Franchini, S; Sorbi, C; Linciano, P; Carnevale, G; Tait, A; Ronsisvalle, S; Buccioni, M; Del Bello, F; Cilia, A; Pirona, L; Denora, N; Iacobazzi, RM; Brasili, L 1,3-Dioxane as a scaffold for potent and selective 5-HT Eur J Med Chem 176:310-325 (2019) [PubMed]  Article 
Target
Name:
Alpha-1B adrenergic receptor
Synonyms:
ADA1B_HUMAN | ADRA1B | Adrenergic alpha1B | Adrenergic receptor | Adrenergic receptor alpha | Alpha 1B-adrenoceptor | Alpha 1B-adrenoreceptor | Alpha-1B adrenergic receptor
Type:
Enzyme
Mol. Mass.:
56862.13
Organism:
Homo sapiens (Human)
Description:
P35368
Residue:
520
Sequence:
MNPDLDTGHNTSAPAHWGELKNANFTGPNQTSSNSTLPQLDITRAISVGLVLGAFILFAIVGNILVILSVACNRHLRTPTNYFIVNLAMADLLLSFTVLPFSAALEVLGYWVLGRIFCDIWAAVDVLCCTASILSLCAISIDRYIGVRYSLQYPTLVTRRKAILALLSVWVLSTVISIGPLLGWKEPAPNDDKECGVTEEPFYALFSSLGSFYIPLAVILVMYCRVYIVAKRTTKNLEAGVMKEMSNSKELTLRIHSKNFHEDTLSSTKAKGHNPRSSIAVKLFKFSREKKAAKTLGIVVGMFILCWLPFFIALPLGSLFSTLKPPDAVFKVVFWLGYFNSCLNPIIYPCSSKEFKRAFVRILGCQCRGRGRRRRRRRRRLGGCAYTYRPWTRGGSLERSQSRKDSLDDSGSCLSGSQRTLPSASPSPGYLGRGAPPPVELCAFPEWKAPGALLSLPAPEPPGRRGRHDSGPLFTFKLLTEPESPGTDGGASNGGCEAAADVANGQPGFKSNMPLAPGQF
  
Inhibitor
Name:
BDBM50409811
Synonyms:
CHEMBL1082862 | CHEMBL286003
Type:
Small organic molecule
Emp. Form.:
C25H27NO4
Mol. Mass.:
405.4862
SMILES:
COc1ccccc1OCCNCC1COC(O1)(c1ccccc1)c1ccccc1
Structure:
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