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Target
Ubiquitin carboxyl-terminal hydrolase 14
Ligand
BDBM50437694
Substrate
n/a
Meas. Tech.
ChEMBL_1855683 (CHEMBL4356412)
IC50
12300±n/a nM
Citation
 Schauer, NJ; Magin, RS; Liu, X; Doherty, LM; Buhrlage, SJ Advances in Discovering Deubiquitinating Enzyme (DUB) Inhibitors. J Med Chem 63:2731-2750 (2020) [PubMed]  Article 
Target
Name:
Ubiquitin carboxyl-terminal hydrolase 14
Synonyms:
Deubiquitinating enzyme 14 | TGT | UBP14_HUMAN | USP14 | Ubiquitin thioesterase 14 | Ubiquitin-specific-processing protease 14
Type:
PROTEIN
Mol. Mass.:
56058.38
Organism:
Homo sapiens (Human)
Description:
ChEMBL_103728
Residue:
494
Sequence:
MPLYSVTVKWGKEKFEGVELNTDEPPMVFKAQLFALTGVQPARQKVMVKGGTLKDDDWGNIKIKNGMTLLMMGSADALPEEPSAKTVFVEDMTEEQLASAMELPCGLTNLGNTCYMNATVQCIRSVPELKDALKRYAGALRASGEMASAQYITAALRDLFDSMDKTSSSIPPIILLQFLHMAFPQFAEKGEQGQYLQQDANECWIQMMRVLQQKLEAIEDDSVKETDSSSASAATPSKKKSLIDQFFGVEFETTMKCTESEEEEVTKGKENQLQLSCFINQEVKYLFTGLKLRLQEEITKQSPTLQRNALYIKSSKISRLPAYLTIQMVRFFYKEKESVNAKVLKDVKFPLMLDMYELCTPELQEKMVSFRSKFKDLEDKKVNQQPNTSDKKSSPQKEVKYEPFSFADDIGSNNCGYYDLQAVLTHQGRSSSSGHYVSWVKRKQDEWIKFDDDKVSIVTPEDILRLSGGGDWHIAYVLLYGPRRVEIMEEESEQ
  
Inhibitor
Name:
BDBM50437694
Synonyms:
CHEMBL1410015
Type:
Small organic molecule
Emp. Form.:
C18H21FN2O
Mol. Mass.:
300.3705
SMILES:
Cc1cc(C(=O)CN2CCCC2)c(C)n1-c1ccc(F)cc1
Structure:
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