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Target
Ubiquitin carboxyl-terminal hydrolase isozyme L1
Ligand
BDBM50514120
Substrate
n/a
Meas. Tech.
ChEMBL_1855680 (CHEMBL4356409)
Ki
400±n/a nM
Citation
 Schauer, NJ; Magin, RS; Liu, X; Doherty, LM; Buhrlage, SJ Advances in Discovering Deubiquitinating Enzyme (DUB) Inhibitors. J Med Chem 63:2731-2750 (2020) [PubMed]  Article 
Target
Name:
Ubiquitin carboxyl-terminal hydrolase isozyme L1
Synonyms:
Neuron cytoplasmic protein 9.5 | PGP 9.5 | PGP9.5 | UCH-L1 | UCHL1 | UCHL1_HUMAN | Ubiquitin thioesterase L1
Type:
PROTEIN
Mol. Mass.:
24819.03
Organism:
Homo sapiens (Human)
Description:
ChEMBL_974327
Residue:
223
Sequence:
MQLKPMEINPEMLNKVLSRLGVAGQWRFVDVLGLEEESLGSVPAPACALLLLFPLTAQHENFRKKQIEELKGQEVSPKVYFMKQTIGNSCGTIGLIHAVANNQDKLGFEDGSVLKQFLSETEKMSPEDRAKCFEKNEAIQAAHDAVAQEGQCRVDDKVNFHFILFNNVDGHLYELDGRMPFPVNHGASSEDTLLKDAAKVCREFTEREQGEVRFSAVALCKAA
  
Inhibitor
Name:
BDBM50514120
Synonyms:
CHEMBL3407553
Type:
Small organic molecule
Emp. Form.:
C17H11Cl3N2O3
Mol. Mass.:
397.64
SMILES:
CC(=O)O\N=C1/C(=O)N(Cc2cc(Cl)ccc2Cl)c2ccc(Cl)cc12
Structure:
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