Reaction Details Report a problem with these data
Target
Nonstructural protein 5A
Ligand
BDBM50514773
Substrate
n/a
Meas. Tech.
ChEMBL_1858471 (CHEMBL4359200)
EC50
3.33±n/a nM
Citation
Kazmierski, WM; Baskaran, S; Walker, JT; Miriyala, N; Meesala, R; Beesu, M; Adjabeng, G; Grimes, RM; Hamatake, R; Leivers, MR; Crosby, R; Xia, B; Remlinger, K GSK2818713, a Novel Biphenylene Scaffold-Based Hepatitis C NS5A Replication Complex Inhibitor with Broad Genotype Coverage. J Med Chem 63:4155-4170 (2020) [PubMed] Article
More Info.:
Target
Name:
Nonstructural protein 5A
Synonyms:
NS5A | Nonstructural protein 5A
Type:
PROTEIN
Mol. Mass.:
48587.20
Organism:
Hepatitis C virus
Description:
ChEMBL_108438
Residue:
447
Sequence:
SGSWLRDVWDWICTVLTDFKTWLQSKLLPRIPGVPFLSCQRGYKGVWRGDGIMHTTCPCGAQITGHVKNGSMRIVGPKTCSNTWHGTFPINTYTTGPCTPSPAPNYSRALWRVAAEEYVEVTRVGDFHYVTGMTTDNVKCPCQVPAPEFFTEVDGVRLHRYAPACKPLLREEVTFMVGLNQYLVGSQLPCEPEPDVTVLTSMLTDPSHITAETAGRRLARGSPPSLASSSASQLSAPSLKATCTTRHDSPDADLIEANLLWRQEMGGNITRVESENKVVILDSFDPLQAEEDEREVSVPAEILRKSRKFPRAMPIWARPDYNPPLLESWKDPDYVPPVVHGCPLPPAKAPPIPPPRRKRTVVLTESTVSSALAELATKTFGSSGSSAVDSGTATAPPDQLPGDGDSGSDVESYSSMPPLEGEPGDPDLSDGSWSTMSEEASEDVVCC
Inhibitor
Name:
BDBM50514773
Synonyms:
CHEMBL4483702
Type:
Small organic molecule
Emp. Form.:
C48H60N8O6
Mol. Mass.:
845.04
SMILES:
[H][C@]12C[C@H](N(C(=O)[C@@H](NC(=O)OC)C(C)C)[C@@]1([H])CCCC2)c1ncc([nH]1)-c1ccc-2c(c1)-c1ccc(cc-21)-c1cnc([nH]1)[C@@H]1C[C@]2([H])CCCC[C@]2([H])N1C(=O)[C@@H](NC(=O)OC)C(C)C |r|