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Target
Kappa-type opioid receptor
Ligand
BDBM50070946
Substrate
n/a
Meas. Tech.
ChEMBL_146389 (CHEMBL753185)
Ki
505±n/a nM
Citation
 Tsai, YC; Liou, JP; Liao, R; Cheng, CY; Tao, PL C-alkylated spiro[benzofuran-3(2H),4'-1'-methyl-piperidine-7-ols] as potent opioids: a conformation-activity study. Bioorg Med Chem Lett 8:1813-8 (1999) [PubMed]  Article 
Target
Name:
Kappa-type opioid receptor
Synonyms:
Kappa Opioid Receptor | OPIATE Kappa | OPRK1 | OPRK_CAVPO | Opiate Kappa 1 | mu/kappa opioid receptor
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
42744.99
Organism:
Cavia porcellus (domestic guinea pig)
Description:
P41144
Residue:
380
Sequence:
MGRRRQGPAQPASELPARNACLLPNGSAWLPGWAEPDGNGSAGPQDEQLEPAHISPAIPVIITAVYSVVFVVGLVGNSLVMFVIIRYTKMKTATNIYIFNLALADALVTTTMPFQSTVYLMNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPLKAKIINICIWLLSSSVGISAIILGGTKVREDVDIIECSLQFPDDDYSWWDLFMKICVFVFAFVIPVLIIIVCYTLMILRLKSVRLLSGSREKDRNLRRITRLVLVVVAVFIICWTPIHIFILVEALGSTSHSTAALSSYYFCIALGYTNSSLNPILYAFLDENFKRCFRDFCFPIKMRMERQSTSRVRNTVQDPAYMRNVDGVNKPV
  
Inhibitor
Name:
BDBM50070946
Synonyms:
1',3'-dimethylspiro[2,3-dihydrobenzo[b]furan-3,4'-(hexahydropyridine)]-7-ol | CHEMBL300689
Type:
Small organic molecule
Emp. Form.:
C14H19NO2
Mol. Mass.:
233.3062
SMILES:
CC1CN(C)CCC11COc2c1cccc2O
Structure:
Search PDB for entries with ligand similarity: