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Target
Substance-P receptor
Ligand
BDBM50070991
Substrate
n/a
Meas. Tech.
ChEBML_141772
IC50
1±n/a nM
Citation
 Elliott, JM; Broughton, H; Cascieri, MA; Chicchi, G; Huscroft, IT; Kurtz, M; MacLeod, AM; Sadowski, S; Stevenson, GI Serine derived NK1 antagonists. 2: A pharmacophore model for arylsulfonamide binding. Bioorg Med Chem Lett 8:1851-6 (1999) [PubMed]  Article 
Target
Name:
Substance-P receptor
Synonyms:
NK-1 receptor | NK-1R | NK1 Receptor | NK1R | NK1R_HUMAN | Neurokinin 1 receptor | Neurokinin-1 (NK-1) | Neuromedin-1 receptor (NK-1R) | SPR | TAC1R | TACR1 | Tachykinin receptor 1 | Tachykinin receptor 1 (NK1) | tachykinin
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
46254.43
Organism:
Homo sapiens (Human)
Description:
P25103
Residue:
407
Sequence:
MDNVLPVDSDLSPNISTNTSEPNQFVQPAWQIVLWAAAYTVIVVTSVVGNVVVMWIILAHKRMRTVTNYFLVNLAFAEASMAAFNTVVNFTYAVHNEWYYGLFYCKFHNFFPIAAVFASIYSMTAVAFDRYMAIIHPLQPRLSATATKVVICVIWVLALLLAFPQGYYSTTETMPSRVVCMIEWPEHPNKIYEKVYHICVTVLIYFLPLLVIGYAYTVVGITLWASEIPGDSSDRYHEQVSAKRKVVKMMIVVVCTFAICWLPFHIFFLLPYINPDLYLKKFIQQVYLAIMWLAMSSTMYNPIIYCCLNDRFRLGFKHAFRCCPFISAGDYEGLEMKSTRYLQTQGSVYKVSRLETTISTVVGAHEEEPEDGPKATPSSLDLTSNCSSRSDSKTMTESFSFSSNVLS
  
Inhibitor
Name:
BDBM50070991
Synonyms:
2-benzylamino-3-(3,4-dichlorobenzyloxy)-1-[1-methylsulfonylspiro[2,3-dihydro-1H-indole-3,4'-(hexahydropyridine)]-1-yl]-(2S)-propan-1-one | CHEMBL53312
Type:
Small organic molecule
Emp. Form.:
C30H33Cl2N3O4S
Mol. Mass.:
602.572
SMILES:
CS(=O)(=O)N1CC2(CCN(CC2)C(=O)[C@H](COCc2ccc(Cl)c(Cl)c2)NCc2ccccc2)c2ccccc12
Structure:
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