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Target
Cholesteryl ester transfer protein
Ligand
BDBM50312718
Substrate
n/a
Meas. Tech.
ChEMBL_1865111 (CHEMBL4366086)
IC50
100±n/a nM
Citation
 Finlay, HJ; Jiang, J; Rampulla, R; Salvati, ME; Qiao, JX; Wang, TC; Lawrence, RM; Harikrishnan, LS; Kamau, MG; Taylor, DS; Chen, AYA; Yin, X; Huang, CS; Chang, M; Chen, XQ; Sleph, PG; Xu, C; Li, J; Levesque, P; Adam, LP; Wexler, RR Discovery of a Lead Triphenylethanamine Cholesterol Ester Transfer Protein (CETP) Inhibitor. ACS Med Chem Lett 10:911-916 (2019) [PubMed]  Article 
Target
Name:
Cholesteryl ester transfer protein
Synonyms:
CETP | CETP_HUMAN | Cholesteryl ester transfer protein (CETP) | Lipid transfer protein I
Type:
Enzyme
Mol. Mass.:
54751.53
Organism:
Homo sapiens (Human)
Description:
P11597
Residue:
493
Sequence:
MLAATVLTLALLGNAHACSKGTSHEAGIVCRITKPALLVLNHETAKVIQTAFQRASYPDITGEKAMMLLGQVKYGLHNIQISHLSIASSQVELVEAKSIDVSIQNVSVVFKGTLKYGYTTAWWLGIDQSIDFEIDSAIDLQINTQLTCDSGRVRTDAPDCYLSFHKLLLHLQGEREPGWIKQLFTNFISFTLKLVLKGQICKEINVISNIMADFVQTRAASILSDGDIGVDISLTGDPVITASYLESHHKGHFIYKNVSEDLPLPTFSPTLLGDSRMLYFWFSERVFHSLAKVAFQDGRLMLSLMGDEFKAVLETWGFNTNQEIFQEVVGGFPSQAQVTVHCLKMPKISCQNKGVVVNSSVMVKFLFPRPDQQHSVAYTFEEDIVTTVQASYSKKKLFLSLLDFQITPKTVSNLTESSSESVQSFLQSMITAVGIPEVMSRLEVVFTALMNSKGVSLFDIINPEIITRDGFLLLQMDFGFPEHLLVDFLQSLS
  
Inhibitor
Name:
BDBM50312718
Synonyms:
CHEMBL479527 | torcetrapib
Type:
Small organic molecule
Emp. Form.:
C26H25F9N2O4
Mol. Mass.:
600.4733
SMILES:
CCOC(=O)N1[C@H](CC)C[C@H](N(Cc2cc(cc(c2)C(F)(F)F)C(F)(F)F)C(=O)OC)c2cc(ccc12)C(F)(F)F |r|
Structure:
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