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Target
5-hydroxytryptamine receptor 6
Ligand
BDBM50516518
Substrate
n/a
Meas. Tech.
ChEMBL_1865787 (CHEMBL4366762)
Ki
111±n/a nM
Citation
 Ali, W; Wi?cek, M; ?a?ewska, D; Kurczab, R; Jastrz?bska-Wi?sek, M; Sata?a, G; Kucwaj-Brysz, K; Lubelska, A; G?uch-Lutwin, M; Mordyl, B; Siwek, A; Nasim, MJ; Partyka, A; Sudo?, S; Latacz, G; Weso?owska, A; Kie?-Kononowicz, K; Handzlik, J Synthesis and computer-aided SAR studies for derivatives of phenoxyalkyl-1,3,5-triazine as the new potent ligands for serotonin receptors 5-HT Eur J Med Chem 178:740-751 (2019) [PubMed]  Article 
Target
Name:
5-hydroxytryptamine receptor 6
Synonyms:
5-HT-6 | 5-HT6 | 5-hydroxytryptamine receptor 6 (5-HT-6) | 5-hydroxytryptamine receptor 6 (5-HT6R) | 5-hydroxytryptamine receptor 6 (5HT6) | 5HT6R_HUMAN | HTR6 | Serotonin (5-HT3) receptor | Serotonin 6 (5-HT6) receptor | Serotonin Receptor 6
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
46968.43
Organism:
Homo sapiens (Human)
Description:
P50406
Residue:
440
Sequence:
MVPEPGPTANSTPAWGAGPPSAPGGSGWVAAALCVVIALTAAANSLLIALICTQPALRNTSNFFLVSLFTSDLMVGLVVMPPAMLNALYGRWVLARGLCLLWTAFDVMCCSASILNLCLISLDRYLLILSPLRYKLRMTPLRALALVLGAWSLAALASFLPLLLGWHELGHARPPVPGQCRLLASLPFVLVASGLTFFLPSGAICFTYCRILLAARKQAVQVASLTTGMASQASETLQVPRTPRPGVESADSRRLATKHSRKALKASLTLGILLGMFFVTWLPFFVANIVQAVCDCISPGLFDVLTWLGYCNSTMNPIIYPLFMRDFKRALGRFLPCPRCPRERQASLASPSLRTSHSGPRPGLSLQQVLPLPLPPDSDSDSDAGSGGSSGLRLTAQLLLPGEATQDPPLPTRAAAAVNFFNIDPAEPELRPHPLGIPTN
  
Inhibitor
Name:
BDBM50516518
Synonyms:
CHEMBL4462404
Type:
Small organic molecule
Emp. Form.:
C16H22N6Se
Mol. Mass.:
377.35
SMILES:
[#6]-[#6]([Se;v2]c1ccccc1)-c1nc(-[#7])nc(n1)-[#7]-1-[#6]-[#6]-[#7](-[#6])-[#6]-[#6]-1
Structure:
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