Reaction Details Report a problem with these data
Target
Cysteinyl leukotriene receptor 1
Ligand
BDBM50073277
Substrate
n/a
Meas. Tech.
ChEBML_52385
Ki
2±n/a nM
Citation
Chambers, RJ; Antognoli, GW; Cheng, JB; Kuperman, AV; Liston, TC; Marfat, A; Owens, BS; Pillar, JS; Shirley, JT; Watson, JW Development of 2,2-dimethylchromanol cysteinyl LT1 receptor antagonists. Bioorg Med Chem Lett 8:3577-82 (1999) [PubMed] Article
More Info.:
Target
Name:
Cysteinyl leukotriene receptor 1
Synonyms:
CLTR1_CAVPO | CYSLTR1
Type:
Enzyme Catalytic Domain
Mol. Mass.:
39007.58
Organism:
GUINEA PIG
Description:
Leukotriene D4 0 GUINEA PIG::Q2NNR5
Residue:
340
Sequence:
MDETGNPTIPPASNNTCYDSIDDFRNQVYSTLYSMISVVGFFGNGFVLYVLVKTYHEKSAFQVYMINLAVADLLCVCTLPLRVAYYVHKGIWLFGDFLCRLSTYALYVNLYCSIFFMTAMSFFRCVAIVFPVQNISLVTQKKARLVCIAIWMFVILTSSPFLMANTYKDEKNNTKCFEPPQDNQAKNYVLILHYVSLFIGFIIPFITIIVCYTMIIFTLLKSSMKKNLSSRKRAIGMIIVVTAAFLVSFMPYHIQRTIHLHFLHNKTKPCDSILRMQKSVVITLSLAASNCCFDPLLYFFSGGNFRRRLSTIRKYSLSSMTYIPKKKTSLPQKGKDICKE
Inhibitor
Name:
BDBM50073277
Synonyms:
CHEMBL332680 | N-{3-[(3S,4R)-6-(5,6-Difluoro-benzothiazol-2-ylmethoxy)-4-hydroxy-2,2-dimethyl-chroman-3-ylmethyl]-4-methoxy-phenyl}-C,C,C-trifluoro-methanesulfonamide
Type:
Small organic molecule
Emp. Form.:
C28H25F5N2O6S2
Mol. Mass.:
644.63
SMILES:
COc1ccc(NS(=O)(=O)C(F)(F)F)cc1C[C@H]1[C@@H](O)c2cc(OCc3nc4cc(F)c(F)cc4s3)ccc2OC1(C)C