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Target
tRNA (guanine-N(1)-)-methyltransferase
Ligand
BDBM50519359
Substrate
n/a
Meas. Tech.
ChEMBL_1874972 (CHEMBL4376261)
IC50
1300±n/a nM
Citation
 Zhong, W; Pasunooti, KK; Balamkundu, S; Wong, YH; Nah, Q; Gadi, V; Gnanakalai, S; Chionh, YH; McBee, ME; Gopal, P; Lim, SH; Olivier, N; Buurman, ET; Dick, T; Liu, CF; Lescar, J; Dedon, PC Thienopyrimidinone Derivatives That Inhibit Bacterial tRNA (Guanine37- J Med Chem 62:7788-7805 (2019) [PubMed]  Article 
Target
Name:
tRNA (guanine-N(1)-)-methyltransferase
Synonyms:
2.1.1.228 | M1G-methyltransferase | TRMD_PSEAE | tRNA (guanine-N(1)-)-methyltransferase | tRNA [GM37] methyltransferase | trmD
Type:
PROTEIN
Mol. Mass.:
28350.59
Organism:
Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM14847 / LMG 12228 / 1C / PRS 101 / PAO1)
Description:
ChEMBL_119649
Residue:
252
Sequence:
MDKRLWVGVVSIFPEMFRAISDYGITSRAVKQGLLTLTCWNPRDYTEDRHQTVDDRPFGGGPGMVMKIKPLEGALADARQAAGGRKAKVIYLSPQGRQLTQAGVRELAEEEALILIAGRYEGIDERFIEEHVDEEWSIGDYVLSGGELPAMVLVDAVTRLLPGALGHADSAEEDSFTDGLLDCPHYTRPEVYADKRVPEVLLSGNHEHIRRWRLQQALGRTWERRADLLDSRSLSGEEQKLLAEYIRQRDDS
  
Inhibitor
Name:
BDBM50519359
Synonyms:
CHEMBL4446167
Type:
Small organic molecule
Emp. Form.:
C27H28N6O7S
Mol. Mass.:
580.612
SMILES:
Oc1cn(O)c(cc1=O)C(=O)NCCCCCC(=O)NCc1ccc(CNC(=O)c2csc3nc[nH]c(=O)c23)cc1
Structure:
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