Reaction Details Report a problem with these data
Target
tRNA (guanine-N(1)-)-methyltransferase
Ligand
BDBM50009672
Substrate
n/a
Meas. Tech.
ChEMBL_1874976 (CHEMBL4376265)
Kd
10100±n/a nM
Citation
Zhong, W; Pasunooti, KK; Balamkundu, S; Wong, YH; Nah, Q; Gadi, V; Gnanakalai, S; Chionh, YH; McBee, ME; Gopal, P; Lim, SH; Olivier, N; Buurman, ET; Dick, T; Liu, CF; Lescar, J; Dedon, PC Thienopyrimidinone Derivatives That Inhibit Bacterial tRNA (Guanine37- J Med Chem 62:7788-7805 (2019) [PubMed] Article
More Info.:
Target
Name:
tRNA (guanine-N(1)-)-methyltransferase
Synonyms:
2.1.1.228 | M1G-methyltransferase | TRMD_MYCTU | tRNA (guanine-N(1)-)-methyltransferase | tRNA [GM37] methyltransferase | trmD
Type:
PROTEIN
Mol. Mass.:
25160.64
Organism:
Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Description:
ChEMBL_119650
Residue:
230
Sequence:
MRIDIVTIFPACLDPLRQSLPGKAIESGLVDLNVHDLRRWTHDVHHSVDDAPYGGGPGMVMKAPVWGEALDEICSSETLLIVPTPAGVLFTQATAQRWTTESHLVFACGRYEGIDQRVVQDAARRMRVEEVSIGDYVLPGGESAAVVMVEAVLRLLAGVLGNPASHQDDSHSTGLDGLLEGPSYTRPASWRGLDVPEVLLSGDHARIAAWRREVSLQRTRERRPDLSHPD
Inhibitor
Name:
BDBM50009672
Synonyms:
AdoHcy | CHEMBL418052 | S-(5'-adenosyl)-L-homocysteine | S-(5'-deoxyadenosin-5'-yl)-L-homocysteine | S-[1-(adenin-9-yl)-1,5-dideoxy-beta-D-ribofuranos-5-yl]-L-homocysteine | S-adenosyl-L-homocysteine | SAH | US8895245, S-Adenosyl-L-homocysteine (SAH) | US9175331, 1 | US9333217, S-Adenosyl-L-homocysteine (SAH)
Type:
Small organic molecule
Emp. Form.:
C14H20N6O5S
Mol. Mass.:
384.411
SMILES:
N[C@@H](CCSC[C@H]1O[C@H]([C@H](O)[C@@H]1O)n1cnc2c(N)ncnc12)C(O)=O