Reaction Details Report a problem with these data
Target
tRNA (guanine-N(1)-)-methyltransferase
Ligand
BDBM50519364
Substrate
n/a
Meas. Tech.
ChEMBL_1874972 (CHEMBL4376261)
IC50
490±n/a nM
Citation
 Zhong, W; Pasunooti, KK; Balamkundu, S; Wong, YH; Nah, Q; Gadi, V; Gnanakalai, S; Chionh, YH; McBee, ME; Gopal, P; Lim, SH; Olivier, N; Buurman, ET; Dick, T; Liu, CF; Lescar, J; Dedon, PC Thienopyrimidinone Derivatives That Inhibit Bacterial tRNA (Guanine37- J Med Chem 62:7788-7805 (2019) [PubMed]  Article 
Target
Name:
tRNA (guanine-N(1)-)-methyltransferase
Synonyms:
2.1.1.228 | M1G-methyltransferase | TRMD_PSEAE | tRNA (guanine-N(1)-)-methyltransferase | tRNA [GM37] methyltransferase | trmD
Type:
PROTEIN
Mol. Mass.:
28350.59
Organism:
Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM14847 / LMG 12228 / 1C / PRS 101 / PAO1)
Description:
ChEMBL_119649
Residue:
252
Sequence:
MDKRLWVGVVSIFPEMFRAISDYGITSRAVKQGLLTLTCWNPRDYTEDRHQTVDDRPFGGGPGMVMKIKPLEGALADARQAAGGRKAKVIYLSPQGRQLTQAGVRELAEEEALILIAGRYEGIDERFIEEHVDEEWSIGDYVLSGGELPAMVLVDAVTRLLPGALGHADSAEEDSFTDGLLDCPHYTRPEVYADKRVPEVLLSGNHEHIRRWRLQQALGRTWERRADLLDSRSLSGEEQKLLAEYIRQRDDS
  
Inhibitor
Name:
BDBM50519364
Synonyms:
CHEMBL4435700
Type:
Small organic molecule
Emp. Form.:
C23H28N4O2S
Mol. Mass.:
424.559
SMILES:
CCN(Cc1ccc(CNC(=O)c2csc3nc[nH]c(=O)c23)cc1)C1CCCCC1
Structure:
Search PDB for entries with ligand similarity: