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Target
Multidrug and toxin extrusion protein 1
Ligand
BDBM50519637
Substrate
n/a
Meas. Tech.
ChEMBL_1877298 (CHEMBL4378692)
IC50
10000±n/a nM
Citation
 Chatzopoulou, M; Claridge, TDW; Davies, KE; Davies, SG; Elsey, DJ; Emer, E; Fletcher, AM; Harriman, S; Robinson, N; Rowley, JA; Russell, AJ; Tinsley, JM; Weaver, R; Wilkinson, IVL; Willis, NJ; Wilson, FX; Wynne, GM Isolation, Structural Identification, Synthesis, and Pharmacological Profiling of 1,2- J Med Chem 63:2547-2556 (2020) [PubMed]  Article 
Target
Name:
Multidrug and toxin extrusion protein 1
Synonyms:
MATE-1 | MATE1 | S47A1_HUMAN | SLC47A1 | Solute carrier family 47 member 1 | hMATE-1
Type:
PROTEIN
Mol. Mass.:
61928.01
Organism:
Homo sapiens (Human)
Description:
ChEMBL_934313
Residue:
570
Sequence:
MEAPEEPAPVRGGPEATLEVRGSRCLRLSAFREELRALLVLAGPAFLVQLMVFLISFISSVFCGHLGKLELDAVTLAIAVINVTGVSVGFGLSSACDTLISQTYGSQNLKHVGVILQRSALVLLLCCFPCWALFLNTQHILLLFRQDPDVSRLTQTYVTIFIPALPATFLYMLQVKYLLNQGIVLPQIVTGVAANLVNALANYLFLHQLHLGVIGSALANLISQYTLALLLFLYILGKKLHQATWGGWSLECLQDWASFLRLAIPSMLMLCMEWWAYEVGSFLSGILGMVELGAQSIVYELAIIVYMVPAGFSVAASVRVGNALGAGDMEQARKSSTVSLLITVLFAVAFSVLLLSCKDHVGYIFTTDRDIINLVAQVVPIYAVSHLFEALACTSGGVLRGSGNQKVGAIVNTIGYYVVGLPIGIALMFATTLGVMGLWSGIIICTVFQAVCFLGFIIQLNWKKACQQAQVHANLKVNNVPRSGNSALPQDPLHPGCPENLEGILTNDVGKTGEPQSDQQMRQEEPLPEHPQDGAKLSRKQLVLRRGLLLLGVFLILLVGILVRFYVRIQ
  
Inhibitor
Name:
BDBM50519637
Synonyms:
CHEMBL4550375
Type:
Small organic molecule
Emp. Form.:
C19H17NO5S
Mol. Mass.:
371.407
SMILES:
CCS(=O)(=O)c1ccc2oc(nc2c1)-c1ccc2[C@H](O)[C@@H](O)C=Cc2c1 |r,c:24|
Structure:
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