Reaction Details Report a problem with these data
Target
N(G),N(G)-dimethylarginine dimethylaminohydrolase 1
Ligand
BDBM50240715
Substrate
n/a
Meas. Tech.
ChEMBL_1878748 (CHEMBL4380142)
Ki
2000±n/a nM
Citation
 Lunk, I; Litty, FA; Hennig, S; Vetter, IR; Kotthaus, J; Altmann, KS; Ott, G; Havemeyer, A; Carrillo García, C; Clement, B; Schade, D Discovery of  J Med Chem 63:425-432 (2020) [PubMed]  Article 
Target
Name:
N(G),N(G)-dimethylarginine dimethylaminohydrolase 1
Synonyms:
DDAH | DDAH1 | DDAH1_HUMAN | Dimethylarginine dimethylaminohydrolase (DDAH-1) | Dimethylarginine dimethylaminohydrolase 1 (DDAH) | Dimethylarginine dimethylaminohydrolase 1 (DDAH) E78A | Dimethylarginine dimethylaminohydrolase 1 (DDAH) L271G | Dimethylarginine dimethylaminohydrolase 1 (DDAH) L30A | Dimethylarginine dimethylaminohydrolase 1 (DDAH1) | N(G),N(G)-dimethylarginine dimethylaminohydrolase 1
Type:
Protein
Mol. Mass.:
31116.90
Organism:
Homo sapiens (Human)
Description:
O94760
Residue:
285
Sequence:
MAGLGHPAAFGRATHAVVRALPESLGQHALRSAKGEEVDVARAERQHQLYVGVLGSKLGLQVVELPADESLPDCVFVEDVAVVCEETALITRPGAPSRRKEVDMMKEALEKLQLNIVEMKDENATLDGGDVLFTGREFFVGLSKRTNQRGAEILADTFKDYAVSTVPVADGLHLKSFCSMAGPNLIAIGSSESAQKALKIMQQMSDHRYDKLTVPDDIAANCIYLNIPNKGHVLLHRTPEEYPESAKVYEKLKDHMLIPVSMSELEKVDGLLTCCSVLINKKVDS
  
Inhibitor
Name:
BDBM50240715
Synonyms:
(S)-2-Amino-5-but-3-enimidoylamino-pentanoic acid | CHEMBL106820 | N5-(1-iminobut-3-enyl)-L-ornithine
Type:
Small organic molecule
Emp. Form.:
C9H17N3O2
Mol. Mass.:
199.2502
SMILES:
CC=CC(N)=NCCC[C@H](N)C(O)=O |r,w:5.5,1.0|
Structure:
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