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Target
Interleukin-1 receptor antagonist protein
Ligand
BDBM50519946
Substrate
n/a
Meas. Tech.
ChEMBL_1878764 (CHEMBL4380158)
IC50
>200000±n/a nM
Citation
 Maben, Z; Arya, R; Rane, D; An, WF; Metkar, S; Hickey, M; Bender, S; Ali, A; Nguyen, TT; Evnouchidou, I; Schilling, R; Stratikos, E; Golden, J; Stern, LJ Discovery of Selective Inhibitors of Endoplasmic Reticulum Aminopeptidase 1. J Med Chem 63:103-121 (2020) [PubMed]  Article 
Target
Name:
Interleukin-1 receptor antagonist protein
Synonyms:
IL-1RN | IL1 inhibitor | IL1RA_MOUSE | IRAP | Il-1ra | Il1rn | Interleukin-1 receptor antagonist protein
Type:
PROTEIN
Mol. Mass.:
20273.13
Organism:
Mus musculus
Description:
ChEMBL_109596
Residue:
178
Sequence:
MEICWGPYSHLISLLLILLFHSEAACRPSGKRPCKMQAFRIWDTNQKTFYLRNNQLIAGYLQGPNIKLEEKIDMVPIDLHSVFLGIHGGKLCLSCAKSGDDIKLQLEEVNITDLSKNKEEDKRFTFIRSEKGPTTSFESAACPGWFLCTTLEADRPVSLTNTPEEPLIVTKFYFQEDQ
  
Inhibitor
Name:
BDBM50519946
Synonyms:
CHEMBL4444617
Type:
Small organic molecule
Emp. Form.:
C20H28FN5O2
Mol. Mass.:
389.467
SMILES:
CC(=O)N1CCN(CC1)C(=O)C1(CCCCC1)NC(=N)Nc1ccc(F)cc1
Structure:
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