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Target
Calcium/calmodulin-dependent protein kinase type II subunit alpha
Ligand
BDBM50520462
Substrate
n/a
Meas. Tech.
ChEMBL_1880296 (CHEMBL4381690)
IC50
840±n/a nM
Citation
 Chen, WC; Simanjuntak, Y; Chu, LW; Ping, YH; Lee, YL; Lin, YL; Li, WS Benzenesulfonamide Derivatives as Calcium/Calmodulin-Dependent Protein Kinase Inhibitors and Antiviral Agents against Dengue and Zika Virus Infections. J Med Chem 63:1313-1327 (2020) [PubMed]  Article 
Target
Name:
Calcium/calmodulin-dependent protein kinase type II subunit alpha
Synonyms:
CAMK2A | CAMKA | CaM kinase II | CaM kinase II alpha | Calcium/calmodulin-dependent protein kinase type II subunit alpha (CAMK2a) | KCC2A_HUMAN | KIAA0968
Type:
Enzyme Catalytic Domain
Mol. Mass.:
54093.63
Organism:
Homo sapiens (Human)
Description:
gi_25952118
Residue:
478
Sequence:
MATITCTRFTEEYQLFEELGKGAFSVVRRCVKVLAGQEYAAKIINTKKLSARDHQKLEREARICRLLKHPNIVRLHDSISEEGHHYLIFDLVTGGELFEDIVAREYYSEADASHCIQQILEAVLHCHQMGVVHRDLKPENLLLASKLKGAAVKLADFGLAIEVEGEQQAWFGFAGTPGYLSPEVLRKDPYGKPVDLWACGVILYILLVGYPPFWDEDQHRLYQQIKAGAYDFPSPEWDTVTPEAKDLINKMLTINPSKRITAAEALKHPWISHRSTVASCMHRQETVDCLKKFNARRKLKGAILTTMLATRNFSGGKSGGNKKSDGVKESSESTNTTIEDEDTKVRKQEIIKVTEQLIEAISNGDFESYTKMCDPGMTAFEPEALGNLVEGLDFHRFYFENLWSRNSKPVHTTILNPHIHLMGDESACIAYIRITQYLDAGGIPRTAQSEETRVWHRRDGKWQIVHFHRSGAPSVLPH
  
Inhibitor
Name:
BDBM50520462
Synonyms:
CHEMBL4515601
Type:
Small organic molecule
Emp. Form.:
C22H27NO4S
Mol. Mass.:
401.519
SMILES:
COc1ccc(cc1)S(=O)(=O)N(CCCC(=O)C1CCCC1)c1ccccc1
Structure:
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