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Target
Genome polyprotein
Ligand
BDBM50075600
Substrate
n/a
Meas. Tech.
ChEMBL_161097 (CHEMBL771558)
EC50
60±n/a nM
Citation
 Dragovich, PS; Prins, TJ; Zhou, R; Fuhrman, SA; Patick, AK; Matthews, DA; Ford, CE; Meador, JW; Ferre, RA; Worland, ST Structure-based design, synthesis, and biological evaluation of irreversible human rhinovirus 3C protease inhibitors. 3. Structure-activity studies of ketomethylene-containing peptidomimetics. J Med Chem 42:1203-12 (1999) [PubMed]  Article 
Target
Name:
Genome polyprotein
Synonyms:
Human rhinovirus A protease | Human rhinovirus B 3A protease
Type:
PROTEIN
Mol. Mass.:
44361.04
Organism:
Human rhinovirus B
Description:
ChEMBL_158953
Residue:
401
Sequence:
AFRPCNVNTKIGNAKCCPFVCGKAVTFKDRSTCSTYNLSSSLHHILEEDKRRRQVVDVMSAIFQGPISLDAPPPPAIADLLQSVRTPRVIKYCQIIMGHPAECQVERDLNIANSIIAIIANIISIAGIIFVIYKLFCSLQGPYSGEPKPKTKVPERRVVAQGPEEEFGRSILKNNTCVITTGNGKFTGLGIHDRILIIPTHADPGREVQVNGVHTKVLDSYDLYNRDGVKLEITVIQLDRNEKFRDIRKYIPETEDDYPECNLALSANQDEPTIIKVGDVVSYGNILLSGNQTARMLKYNYPTKSGYCGGVLYKIGQILGIHVGGNGRDGFSAMLLRSYFTGQIKVNKHATECGLPDIQTIHTPSKTKLQPSVFYDVFPGSKEPAVLTDNDPRLEVNFKEA
  
Inhibitor
Name:
BDBM50075600
Synonyms:
(E)-(S)-6-Carbamoyl-4-[(2R,5S)-5-cyclopentylsulfanylcarbonylamino-6-methyl-2-(4-methyl-benzyl)-4-oxo-heptanoylamino]-hex-2-enoic acid ethyl ester | CHEMBL19888
Type:
Small organic molecule
Emp. Form.:
C31H45N3O6S
Mol. Mass.:
587.771
SMILES:
CCOC(=O)\C=C\[C@H](CCC(N)=O)NC(=O)[C@@H](CC(=O)[C@@H](NC(=O)SC1CCCC1)C(C)C)Cc1ccc(C)cc1
Structure:
Search PDB for entries with ligand similarity: