Reaction Details Report a problem with these data
Target
Coagulation factor X
Ligand
BDBM50066631
Substrate
n/a
Meas. Tech.
ChEMBL_48800 (CHEMBL838886)
Ki
620±n/a nM
Citation
Phillips, G; Davey, DD; Eagen, KA; Koovakkat, SK; Liang, A; Ng, HP; Pinkerton, M; Trinh, L; Whitlow, M; Beatty, AM; Morrissey, MM Design, synthesis, and activity of 2,6-diphenoxypyridine-derived factor Xa inhibitors. J Med Chem 42:1749-56 (1999) [PubMed] Article
More Info.:
Target
Name:
Coagulation factor X
Synonyms:
Activated coagulation factor X (FXa) | Activated factor Xa heavy chain | Coagulation factor X precursor | Coagulation factor Xa | F10 | FA10_HUMAN | Factor X heavy chain | Factor X light chain | Factor Xa | Stuart factor | Stuart-Prower factor
Type:
Enzyme
Mol. Mass.:
54726.60
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
488
Sequence:
MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK
Inhibitor
Name:
BDBM50066631
Synonyms:
4-[3,5-Dichloro-6-(4-diaminomethyl-phenoxy)-pyridin-2-yloxy]-benzamidine | 4-{6-[4-amino(imino)methylphenoxy]-3,5-dichloro-2-pyridyloxy}phenyl-iminomethanamine | CHEMBL49786
Type:
Small organic molecule
Emp. Form.:
C19H15Cl2N5O2
Mol. Mass.:
416.261
SMILES:
NC(=N)c1ccc(Oc2nc(Oc3ccc(cc3)C(N)=N)c(Cl)cc2Cl)cc1