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Target
Glucagon receptor
Ligand
BDBM50522720
Substrate
n/a
Meas. Tech.
ChEMBL_1888365 (CHEMBL4390042)
Ki
57±n/a nM
Citation
 Song, F; Xu, G; Gaul, MD; Zhao, B; Lu, T; Zhang, R; DesJarlais, RL; DiLoreto, K; Huebert, N; Shook, B; Rentzeperis, D; Santulli, R; Eckardt, A; Demarest, K Design, synthesis and structure activity relationships of indazole and indole derivatives as potent glucagon receptor antagonists. Bioorg Med Chem Lett 29:1974-1980 (2019) [PubMed]  Article 
Target
Name:
Glucagon receptor
Synonyms:
GCGR | GL-R | GLR_HUMAN | Glucagon Receptor (GCGR) | Glucagon receptor (GlucR)
Type:
Enzyme
Mol. Mass.:
54026.92
Organism:
Homo sapiens (Human)
Description:
P47871
Residue:
477
Sequence:
MPPCQPQRPLLLLLLLLACQPQVPSAQVMDFLFEKWKLYGDQCHHNLSLLPPPTELVCNRTFDKYSCWPDTPANTTANISCPWYLPWHHKVQHRFVFKRCGPDGQWVRGPRGQPWRDASQCQMDGEEIEVQKEVAKMYSSFQVMYTVGYSLSLGALLLALAILGGLSKLHCTRNAIHANLFASFVLKASSVLVIDGLLRTRYSQKIGDDLSVSTWLSDGAVAGCRVAAVFMQYGIVANYCWLLVEGLYLHNLLGLATLPERSFFSLYLGIGWGAPMLFVVPWAVVKCLFENVQCWTSNDNMGFWWILRFPVFLAILINFFIFVRIVQLLVAKLRARQMHHTDYKFRLAKSTLTLIPLLGVHEVVFAFVTDEHAQGTLRSAKLFFDLFLSSFQGLLVAVLYCFLNKEVQSELRRRWHRWRLGKVLWEERNTSNHRASSSPGHGPPSKELQFGRGGGSQDSSAETPLAGGLPRLAESPF
  
Inhibitor
Name:
BDBM50522720
Synonyms:
CHEMBL4456601
Type:
Small organic molecule
Emp. Form.:
C30H30ClF3N4O4
Mol. Mass.:
603.032
SMILES:
CCOc1c(ccc2nn(cc12)C(CC(C)C)c1ccc(nc1)C(=O)NCCC(O)=O)-c1ccc(cc1Cl)C(F)(F)F
Structure:
Search PDB for entries with ligand similarity: