Reaction Details Report a problem with these data
Target
Renin
Ligand
BDBM50077696
Substrate
n/a
Meas. Tech.
ChEMBL_195757 (CHEMBL803424)
IC50
12±n/a nM
Citation
Güller, R; Binggeli, A; Breu, V; Bur, D; Fischli, W; Hirth, G; Jenny, C; Kansy, M; Montavon, F; Müller, M; Oefner, C; Stadler, H; Vieira, E; Wilhelm, M; Wostl, W; Märki, HP Piperidine-renin inhibitors compounds with improved physicochemical properties. Bioorg Med Chem Lett 9:1403-8 (1999) [PubMed] Article
More Info.:
Target
Name:
Renin
Synonyms:
Angiotensinogenase | REN | RENI_HUMAN
Type:
Enzyme
Mol. Mass.:
45058.99
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
406
Sequence:
MDGWRRMPRWGLLLLLWGSCTFGLPTDTTTFKRIFLKRMPSIRESLKERGVDMARLGPEWSQPMKRLTLGNTTSSVILTNYMDTQYYGEIGIGTPPQTFKVVFDTGSSNVWVPSSKCSRLYTACVYHKLFDASDSSSYKHNGTELTLRYSTGTVSGFLSQDIITVGGITVTQMFGEVTEMPALPFMLAEFDGVVGMGFIEQAIGRVTPIFDNIISQGVLKEDVFSFYYNRDSENSQSLGGQIVLGGSDPQHYEGNFHYINLIKTGVWQIQMKGVSVGSSTLLCEDGCLALVDTGASYISGSTSSIEKLMEALGAKKRLFDYVVKCNEGPTLPDISFHLGGKEYTLTSADYVFQESYSSKKLCTLAIHAMDIPPPTGPTWALGATFIRKFYTEFDRRNNRIGFALAR
Inhibitor
Name:
BDBM50077696
Synonyms:
4-[2-(7-{(3R,4R)-4-[4-(3-Benzyloxy-propoxy)-phenyl]-piperidin-3-yloxymethyl}-naphthalen-2-yloxy)-ethyl]-morpholine | CHEMBL285779
Type:
Small organic molecule
Emp. Form.:
C38H46N2O5
Mol. Mass.:
610.7822
SMILES:
C(COCc1ccccc1)COc1ccc(cc1)[C@H]1CCNC[C@@H]1OCc1ccc2ccc(OCCN3CCOCC3)cc2c1