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Found 115 with Last Name = 'breu' and Initial = 'v'
TargetRenin(Homo sapiens (Human))
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50077669((S)-2-Benzyl-N-[(S)-1-((1S,2R,3S)-1-cyclohexylmeth...)
Affinity DataIC50:  0.0250nMAssay Description:In vitro inhibitory activity against purified recombinant human reninMore data for this Ligand-Target Pair
TargetRenin(Homo sapiens (Human))
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50077678((3R,4R)-3-(1,4-Dimethoxy-naphthalen-2-ylmethoxy)-4...)
Affinity DataIC50:  0.0600nMAssay Description:In vitro inhibitory activity against purified recombinant human reninMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRenin(Homo sapiens (Human))
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50077678((3R,4R)-3-(1,4-Dimethoxy-naphthalen-2-ylmethoxy)-4...)
Affinity DataIC50:  0.0870nMAssay Description:Inhibitory activity against purified recombinant human reninMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEndothelin-1 receptor(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50000558(CHEMBL437472 | ET-1 | Endothelin -1 | Endothelin 1...)
Affinity DataIC50:  0.200nMAssay Description:Receptor binding affinity was determined against [125I]ET1 with recombinant human ETA receptor, expressed in baculovirus-infected Sf9 cellsMore data for this Ligand-Target Pair
In DepthDetails Article
TargetEndothelin receptor type B(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50000558(CHEMBL437472 | ET-1 | Endothelin -1 | Endothelin 1...)
Affinity DataIC50:  0.200nMAssay Description:Receptor binding affinity was determined against [125I]ET1 with membranes prepared from human placenta for ETB receptorMore data for this Ligand-Target Pair
In DepthDetails Article
TargetEndothelin-1 receptor(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50290050(CHEMBL70385 | Pyridin-2-yl-carbamic acid 2-[5-(2-m...)
Affinity DataIC50:  0.200nMAssay Description:Receptor binding affinity was determined against [125I]ET1 with recombinant human ETA receptor, expressed in baculovirus-infected Sf9 cellsMore data for this Ligand-Target Pair
In DepthDetails Article
TargetEndothelin-1 receptor(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50290043(CHEMBL72037 | Pyridin-2-yl-carbamic acid 2-[6-(5-i...)
Affinity DataIC50:  0.300nMAssay Description:Receptor binding affinity was determined against [125I]ET1 with recombinant human ETA receptor, expressed in baculovirus-infected Sf9 cellsMore data for this Ligand-Target Pair
In DepthDetails Article
TargetEndothelin-1 receptor(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50000558(CHEMBL437472 | ET-1 | Endothelin -1 | Endothelin 1...)
Affinity DataIC50:  0.300nMAssay Description:Evaluation for functional inhibitory potency prevention of ET-1 induced constriction of rat aortic rings (ETA receptors)More data for this Ligand-Target Pair
In DepthDetails Article
TargetRenin(Homo sapiens (Human))
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50077702(4-[(3S,4R,5R)-4-[4-(3-Benzyloxy-propoxy)-phenyl]-5...)
Affinity DataIC50:  0.400nMAssay Description:Inhibitory activity against purified recombinant human reninMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRenin(Homo sapiens (Human))
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50077693((3'R,4'R)-3'-(1,4-Dimethoxy-naphthalen-2-ylmethoxy...)
Affinity DataIC50:  0.5nMAssay Description:Inhibitory activity against purified recombinant human reninMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRenin(Homo sapiens (Human))
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50077699(7-((3R,4R)-4-{4-[3-(2-Methoxy-benzyloxy)-propoxy]-...)
Affinity DataIC50:  0.670nMAssay Description:Inhibitory activity against human plasma reninMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEndothelin-1 receptor(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50290043(CHEMBL72037 | Pyridin-2-yl-carbamic acid 2-[6-(5-i...)
Affinity DataIC50:  0.700nMAssay Description:Evaluation for functional inhibitory potency prevention of ET-1 induced constriction of rat aortic rings (ETA receptors)More data for this Ligand-Target Pair
In DepthDetails Article
TargetRenin(Homo sapiens (Human))
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50077692((3R,4R,5S)-4-[4-(3-Benzyloxy-propoxy)-phenyl]-3-(n...)
Affinity DataIC50:  0.920nMAssay Description:Inhibitory activity against purified recombinant human reninMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEndothelin-1 receptor(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50290047(CHEMBL308088 | Pyridin-2-yl-carbamic acid 2-[6-(5-...)
Affinity DataIC50:  1nMAssay Description:Receptor binding affinity was determined against [125I]ET1 with recombinant human ETA receptor, expressed in baculovirus-infected Sf9 cellsMore data for this Ligand-Target Pair
In DepthDetails Article
TargetRenin(Homo sapiens (Human))
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50077688((3R,4R)-4-{4-[3-(2-Methoxy-benzyloxy)-propoxy]-phe...)
Affinity DataIC50:  1.5nMAssay Description:In vitro inhibitory activity against purified recombinant human reninMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRenin(Homo sapiens (Human))
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50077703(4-{2-[(3S,4R,5R)-4-[4-(3-Benzyloxy-propoxy)-phenyl...)
Affinity DataIC50:  1.80nMAssay Description:Inhibitory activity against purified recombinant human reninMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRenin(Homo sapiens (Human))
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50077704(CHEMBL31880 | Sulfuric acid mono-[(3S,4R,5R)-4-[4-...)
Affinity DataIC50:  2.30nMAssay Description:Inhibitory activity against human plasma reninMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEndothelin-1 receptor(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50290059(CHEMBL70895 | Pyridin-2-yl-carbamic acid 2-[6-(5-i...)
Affinity DataIC50:  3nMAssay Description:Receptor binding affinity was determined against [125I]ET1 with recombinant human ETA receptor, expressed in baculovirus-infected Sf9 cellsMore data for this Ligand-Target Pair
In DepthDetails Article
TargetRenin(Homo sapiens (Human))
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50077709(4-{2-[(3S,4R,5R)-4-[4-(3-Benzyloxy-propoxy)-phenyl...)
Affinity DataIC50:  3.30nMAssay Description:Inhibitory activity against purified recombinant human reninMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEndothelin-1 receptor(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50290060(CHEMBL70293 | Pyridin-2-yl-carbamic acid 2-[6-(5-i...)
Affinity DataIC50:  4nMAssay Description:Receptor binding affinity was determined against [125I]ET1 with recombinant human ETA receptor, expressed in baculovirus-infected Sf9 cellsMore data for this Ligand-Target Pair
In DepthDetails Article
TargetEndothelin-1 receptor(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50290057(CHEMBL70303 | Pyridin-2-yl-carbamic acid 2-[5-(2-m...)
Affinity DataIC50:  4nMAssay Description:Receptor binding affinity was determined against [125I]ET1 with recombinant human ETA receptor, expressed in baculovirus-infected Sf9 cellsMore data for this Ligand-Target Pair
In DepthDetails Article
TargetRenin(Homo sapiens (Human))
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50077695(7-((3R,4R)-4-{4-[3-(2-Methoxy-benzyloxy)-propoxy]-...)
Affinity DataIC50:  4nMAssay Description:Inhibitory activity against purified recombinant human reninMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRenin(Homo sapiens (Human))
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50077689((3R,4R)-4-[4-(3-Benzyloxy-propoxy)-phenyl]-3-(naph...)
Affinity DataIC50:  5nMAssay Description:Inhibitory activity against purified recombinant human reninMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEndothelin receptor type B(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50290043(CHEMBL72037 | Pyridin-2-yl-carbamic acid 2-[6-(5-i...)
Affinity DataIC50:  5nMAssay Description:Receptor binding affinity was determined against [125I]ET1 with membranes prepared from human placenta for ETB receptorMore data for this Ligand-Target Pair
In DepthDetails Article
TargetRenin(Homo sapiens (Human))
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50077694(7-{(3R,4R)-4-[4-(3-Benzyloxy-propoxy)-phenyl]-pipe...)
Affinity DataIC50:  5.10nMAssay Description:Inhibitory activity against purified recombinant human reninMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEndothelin-1 receptor(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50290044(CHEMBL70800 | Pyridin-2-yl-carbamic acid 2-[6-(4-t...)
Affinity DataIC50:  6nMAssay Description:Receptor binding affinity was determined against [125I]ET1 with recombinant human ETA receptor, expressed in baculovirus-infected Sf9 cellsMore data for this Ligand-Target Pair
In DepthDetails Article
TargetEndothelin-1 receptor(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50290041(CHEMBL70203 | Pyridin-2-yl-carbamic acid 2-[6-(4-t...)
Affinity DataIC50:  6nMAssay Description:Receptor binding affinity was determined against [125I]ET1 with recombinant human ETA receptor, expressed in baculovirus-infected Sf9 cellsMore data for this Ligand-Target Pair
In DepthDetails Article
TargetRenin(Homo sapiens (Human))
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50077705((3S,4S,5R)-4-[4-(3-Benzyloxy-propoxy)-phenyl]-5-(n...)
Affinity DataIC50:  6.40nMAssay Description:Inhibitory activity against purified recombinant human reninMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEndothelin-1 receptor(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50290049(CHEMBL71070 | Pyridin-2-yl-carbamic acid 2-[6-(4-t...)
Affinity DataIC50:  7nMAssay Description:Receptor binding affinity was determined against [125I]ET1 with recombinant human ETA receptor, expressed in baculovirus-infected Sf9 cellsMore data for this Ligand-Target Pair
In DepthDetails Article
TargetEndothelin-1 receptor(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50290042(CHEMBL70487 | Pyridin-2-yl-carbamic acid 2-[6-(4-t...)
Affinity DataIC50:  7nMAssay Description:Receptor binding affinity was determined against [125I]ET1 with recombinant human ETA receptor, expressed in baculovirus-infected Sf9 cellsMore data for this Ligand-Target Pair
In DepthDetails Article
TargetRenin(Homo sapiens (Human))
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50077697(7-((3R,4R)-4-{4-[3-(2-Methoxy-benzyloxy)-propoxy]-...)
Affinity DataIC50:  8nMAssay Description:Inhibitory activity against purified recombinant human reninMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRenin(Homo sapiens (Human))
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50077689((3R,4R)-4-[4-(3-Benzyloxy-propoxy)-phenyl]-3-(naph...)
Affinity DataIC50:  8nMAssay Description:In vitro inhibitory activity against purified recombinant human reninMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEndothelin-1 receptor(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50290055(CHEMBL303428 | Pyridin-2-yl-carbamic acid 2-[6-(4-...)
Affinity DataIC50:  9nMAssay Description:Receptor binding affinity was determined against [125I]ET1 with recombinant human ETA receptor, expressed in baculovirus-infected Sf9 cellsMore data for this Ligand-Target Pair
In DepthDetails Article
TargetRenin(Homo sapiens (Human))
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50077707((3R,4S,5R)-4-[4-(3-Benzyloxy-propoxy)-phenyl]-5-(n...)
Affinity DataIC50:  9nMAssay Description:Inhibitory activity against purified recombinant human reninMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRenin(Homo sapiens (Human))
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50077698(5-[(3R,4R)-3-(1,4-Dimethoxy-naphthalen-2-ylmethoxy...)
Affinity DataIC50:  10nMAssay Description:Inhibitory activity against purified recombinant human reninMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRenin(Homo sapiens (Human))
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50077678((3R,4R)-3-(1,4-Dimethoxy-naphthalen-2-ylmethoxy)-4...)
Affinity DataIC50:  12nMAssay Description:Inhibitory activity against human plasma reninMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRenin(Homo sapiens (Human))
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50077706(7-{(3R,4R)-4-[4-(3-Benzyloxy-propoxy)-phenyl]-pipe...)
Affinity DataIC50:  12nMAssay Description:Inhibitory activity against purified recombinant human reninMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRenin(Homo sapiens (Human))
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50077696(4-[2-(7-{(3R,4R)-4-[4-(3-Benzyloxy-propoxy)-phenyl...)
Affinity DataIC50:  12nMAssay Description:Inhibitory activity against human plasma reninMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEndothelin receptor type B(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50290047(CHEMBL308088 | Pyridin-2-yl-carbamic acid 2-[6-(5-...)
Affinity DataIC50:  14nMAssay Description:Receptor binding affinity was determined against [125I]ET1 with membranes prepared from human placenta for ETB receptorMore data for this Ligand-Target Pair
In DepthDetails Article
TargetEndothelin-1 receptor(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50290051(CHEMBL303649 | Pyridin-2-yl-carbamic acid 2-[2-ter...)
Affinity DataIC50:  14nMAssay Description:Receptor binding affinity was determined against [125I]ET1 with recombinant human ETA receptor, expressed in baculovirus-infected Sf9 cellsMore data for this Ligand-Target Pair
In DepthDetails Article
TargetEndothelin-1 receptor(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50290053(CHEMBL70339 | Pyridin-2-yl-carbamic acid 2-[6-(4-t...)
Affinity DataIC50:  17nMAssay Description:Receptor binding affinity was determined against [125I]ET1 with recombinant human ETA receptor, expressed in baculovirus-infected Sf9 cellsMore data for this Ligand-Target Pair
In DepthDetails Article
TargetEndothelin receptor type B(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50290053(CHEMBL70339 | Pyridin-2-yl-carbamic acid 2-[6-(4-t...)
Affinity DataIC50:  19nMAssay Description:Receptor binding affinity was determined against [125I]ET1 with membranes prepared from human placenta for ETB receptorMore data for this Ligand-Target Pair
In DepthDetails Article
TargetRenin(Homo sapiens (Human))
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50077708(4-[2-(6-{(3R,4R)-4-[4-(3-Benzyloxy-propoxy)-phenyl...)
Affinity DataIC50:  22nMAssay Description:Inhibitory activity against human plasma reninMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEndothelin receptor type B(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50290050(CHEMBL70385 | Pyridin-2-yl-carbamic acid 2-[5-(2-m...)
Affinity DataIC50:  25nMAssay Description:Receptor binding affinity was determined against [125I]ET1 with membranes prepared from human placenta for ETB receptorMore data for this Ligand-Target Pair
In DepthDetails Article
TargetEndothelin receptor type B(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50290059(CHEMBL70895 | Pyridin-2-yl-carbamic acid 2-[6-(5-i...)
Affinity DataIC50:  25nMAssay Description:Receptor binding affinity was determined against [125I]ET1 with membranes prepared from human placenta for ETB receptorMore data for this Ligand-Target Pair
In DepthDetails Article
TargetRenin(Homo sapiens (Human))
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50077682(Benzoic acid 2-{4-[(3R,4R)-3-(naphthalen-2-ylmetho...)
Affinity DataIC50:  26nMAssay Description:In vitro inhibitory activity against purified recombinant human reninMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEndothelin-1 receptor(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50290061(CHEMBL70365 | Pyridin-2-yl-carbamic acid 2-[6-(4-t...)
Affinity DataIC50:  30nMAssay Description:Receptor binding affinity was determined against [125I]ET1 with recombinant human ETA receptor, expressed in baculovirus-infected Sf9 cellsMore data for this Ligand-Target Pair
In DepthDetails Article
TargetRenin(Homo sapiens (Human))
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50077699(7-((3R,4R)-4-{4-[3-(2-Methoxy-benzyloxy)-propoxy]-...)
Affinity DataIC50:  37nMAssay Description:Inhibitory activity against human plasma reninMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRenin(Homo sapiens (Human))
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50077671((3R,4R)-3-(Naphthalen-2-ylmethoxy)-4-[4-(3-phenyl-...)
Affinity DataIC50:  41nMAssay Description:In vitro inhibitory activity against purified recombinant human reninMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEndothelin receptor type B(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50290041(CHEMBL70203 | Pyridin-2-yl-carbamic acid 2-[6-(4-t...)
Affinity DataIC50:  43nMAssay Description:Receptor binding affinity was determined against [125I]ET1 with membranes prepared from human placenta for ETB receptorMore data for this Ligand-Target Pair
In DepthDetails Article
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