Reaction Details Report a problem with these data
Target
Renin
Ligand
BDBM50077705
Substrate
n/a
Meas. Tech.
ChEMBL_195757 (CHEMBL803424)
IC50
6.4±n/a nM
Citation
 Güller, R; Binggeli, A; Breu, V; Bur, D; Fischli, W; Hirth, G; Jenny, C; Kansy, M; Montavon, F; Müller, M; Oefner, C; Stadler, H; Vieira, E; Wilhelm, M; Wostl, W; Märki, HP Piperidine-renin inhibitors compounds with improved physicochemical properties. Bioorg Med Chem Lett 9:1403-8 (1999) [PubMed]  Article 
Target
Name:
Renin
Synonyms:
Angiotensinogenase | REN | RENI_HUMAN
Type:
Enzyme
Mol. Mass.:
45058.99
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
406
Sequence:
MDGWRRMPRWGLLLLLWGSCTFGLPTDTTTFKRIFLKRMPSIRESLKERGVDMARLGPEWSQPMKRLTLGNTTSSVILTNYMDTQYYGEIGIGTPPQTFKVVFDTGSSNVWVPSSKCSRLYTACVYHKLFDASDSSSYKHNGTELTLRYSTGTVSGFLSQDIITVGGITVTQMFGEVTEMPALPFMLAEFDGVVGMGFIEQAIGRVTPIFDNIISQGVLKEDVFSFYYNRDSENSQSLGGQIVLGGSDPQHYEGNFHYINLIKTGVWQIQMKGVSVGSSTLLCEDGCLALVDTGASYISGSTSSIEKLMEALGAKKRLFDYVVKCNEGPTLPDISFHLGGKEYTLTSADYVFQESYSSKKLCTLAIHAMDIPPPTGPTWALGATFIRKFYTEFDRRNNRIGFALAR
  
Inhibitor
Name:
BDBM50077705
Synonyms:
(3S,4S,5R)-4-[4-(3-Benzyloxy-propoxy)-phenyl]-5-(naphthalen-2-ylmethoxy)-piperidin-3-ol | CHEMBL281299
Type:
Small organic molecule
Emp. Form.:
C32H35NO4
Mol. Mass.:
497.6246
SMILES:
O[C@@H]1CNC[C@H](OCc2ccc3ccccc3c2)[C@H]1c1ccc(OCCCOCc2ccccc2)cc1
Structure:
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