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Target
Corticotropin-releasing factor receptor 1
Ligand
BDBM50054255
Substrate
n/a
Meas. Tech.
ChEMBL_50976 (CHEMBL663519)
Ki
1390±n/a nM
Citation
 Keller, PA; Bowman, M; Dang, KH; Garner, J; Leach, SP; Smith, R; McCluskey, A Pharmacophore development for corticotropin-releasing hormone: new insights into inhibitor activity. J Med Chem 42:2351-7 (1999) [PubMed]  Article 
Target
Name:
Corticotropin-releasing factor receptor 1
Synonyms:
CRF-R | CRF-R2 Alpha | CRF1 | CRFR | CRFR1 | CRFR1_HUMAN | CRH-R 1 | CRHR | CRHR1 | Corticotropin releasing factor receptor 1 | Corticotropin-releasing factor receptor 1 (CRF-1) | Corticotropin-releasing factor receptor 1 (CRF1) | Corticotropin-releasing hormone receptor 1
Type:
Enzyme
Mol. Mass.:
50744.31
Organism:
Homo sapiens (Human)
Description:
P34998
Residue:
444
Sequence:
MGGHPQLRLVKALLLLGLNPVSASLQDQHCESLSLASNISGLQCNASVDLIGTCWPRSPAGQLVVRPCPAFFYGVRYNTTNNGYRECLANGSWAARVNYSECQEILNEEKKSKVHYHVAVIINYLGHCISLVALLVAFVLFLRLRPGCTHWGDQADGALEVGAPWSGAPFQVRRSIRCLRNIIHWNLISAFILRNATWFVVQLTMSPEVHQSNVGWCRLVTAAYNYFHVTNFFWMFGEGCYLHTAIVLTYSTDRLRKWMFICIGWGVPFPIIVAWAIGKLYYDNEKCWFGKRPGVYTDYIYQGPMILVLLINFIFLFNIVRILMTKLRASTTSETIQYRKAVKATLVLLPLLGITYMLFFVNPGEDEVSRVVFIYFNSFLESFQGFFVSVFYCFLNSEVRSAIRKRWHRWQDKHSIRARVARAMSIPTSPTRVSFHSIKQSTAV
  
Inhibitor
Name:
BDBM50054255
Synonyms:
CHEMBL80806 | N-Cyclopropylmethyl-2-methyl-N-propyl-N'-(2,4,6-trimethyl-phenyl)-pyrimidine-4,6-diamine
Type:
Small organic molecule
Emp. Form.:
C21H30N4
Mol. Mass.:
338.4897
SMILES:
CCCN(CC1CC1)c1cc(Nc2c(C)cc(C)cc2C)nc(C)n1
Structure:
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