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Found 423 with Last Name = 'mccluskey' and Initial = 'a'
TargetMelanocortin receptor 4(Homo sapiens (Human))
The University Of Newcastle

Curated by ChEMBL
LigandPNGBDBM50128358(CHEMBL3629347)
Affinity DataKi:  0.140nMAssay Description:Inhibition of human recombinant melanocortin 4 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 7(Homo sapiens (Human))
The University Of Newcastle

Curated by ChEMBL
LigandPNGBDBM10755(14C-5-hydroxy tryptamine creatinine disulfate | 2-...)
Affinity DataKi:  0.170nMAssay Description:Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO cells after 120 mins by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMuscarinic acetylcholine receptor M3(Homo sapiens (Human))
The University Of Newcastle

Curated by ChEMBL
LigandPNGBDBM50176065(4-DAMP | 4-Diphenylacetoxy-1,1-dimethyl-piperidini...)
Affinity DataKi:  0.220nMAssay Description:Displacement of [3H]4-DAMP from human recombinant Muscarinic acetylcholine receptor M3 expressed in CHO cells after 60 mins by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(2) dopamine receptor(Homo sapiens (Human))
The University Of Newcastle

Curated by ChEMBL
LigandPNGBDBM50008735((+)-3-(tert-butyl)-(3S,4aS,13bS)-2,3,4,4a,8,9,13b,...)
Affinity DataKi:  0.270nMAssay Description:Displacement of [3H]methyl-spiperone from human recombinant D2S receptor in HEK293 cells after 60 mins by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 2A(Homo sapiens (Human))
The University Of Newcastle

Curated by ChEMBL
LigandPNGBDBM21395(3-(2-(4-(4-Fluorobenzoyl)piperidinol)ethyl)-2,4(1H...)
Affinity DataKi:  0.280nMAssay Description:Displacement of [3H]ketanserin from human recombinant 5-HT2A receptor in HEK293 cells after 60 mins by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKappa-type opioid receptor(Rattus norvegicus (rat))
The University Of Newcastle

Curated by ChEMBL
LigandPNGBDBM50000296(CHEMBL441765 | CHEMBL482811 | U-50488H | US1149237...)
Affinity DataKi:  0.450nMAssay Description:Displacement of [3H]U 69593 from rat recombinant kappa opioid receptor expressed in CHO cells after 60 mins by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H1 receptor(Homo sapiens (Human))
The University Of Newcastle

Curated by ChEMBL
LigandPNGBDBM22567(3H]pyrilamine | CHEMBL511 | Dorantamin | Mepyramin...)
Affinity DataKi:  0.710nMAssay Description:Displacement of [3H]pyrilamine from human recombinant histamine H1 receptor in HEK293 cells after 60 mins by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank

Target5-hydroxytryptamine receptor 2B(Homo sapiens (Human))
The University Of Newcastle

Curated by ChEMBL
LigandPNGBDBM28582(1-(4-iodo-2,5-dimethoxyphenyl)propan-2-amine | CHE...)
Affinity DataKi:  1.60nMAssay Description:Displacement of [125I](+/-)DOI from human recombinant 5-HT2B receptor expressed in CHO cells after 60 mins by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCorticotropin-releasing factor receptor 1(Homo sapiens (Human))
The University Of Wollongong

Curated by ChEMBL
LigandPNGBDBM50054245(5-Chloro-N-cyclopropylmethyl-2-methyl-N-propyl-N''...)
Affinity DataKi:  1.70nMAssay Description:Inhibition of [125I]-CRH binding to human Corticotropin releasing factor receptor 1.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCorticotropin-releasing factor receptor 1(Homo sapiens (Human))
The University Of Wollongong

Curated by ChEMBL
LigandPNGBDBM50054252(5-Bromo-N-cyclopropylmethyl-2-methyl-N-propyl-N'-(...)
Affinity DataKi:  2nMAssay Description:Ability to inhibit [125I]-CRH binding to human Corticotropin releasing factor receptor 1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSubstance-K receptor(Homo sapiens (Human))
The University Of Newcastle

Curated by ChEMBL
LigandPNGBDBM50233962(CHEMBL4068783)
Affinity DataKi:  2nMAssay Description:Displacement of [125I]NKA from human recombinant tachykinin NK2 receptor expressed in CHO cells after 60 mins by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent noradrenaline transporter(Homo sapiens (Human))
The University Of Newcastle

Curated by ChEMBL
LigandPNGBDBM50176062(3-(5H-dibenzo[a,d][7]annulen-5-yl)-N-methylpropan-...)
Affinity DataKi:  2.10nMAssay Description:Displacement of [3H]nisoxetine from human recombinant norepinephrine transporter expressed in CHO cells after 120 mins by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank

TargetCorticotropin-releasing factor receptor 1(Homo sapiens (Human))
The University Of Wollongong

Curated by ChEMBL
LigandPNGBDBM50054250(CHEMBL306482 | N-Cyclopropylmethyl-2,5-dimethyl-N-...)
Affinity DataKi:  2.30nMAssay Description:Inhibition of [125I]-CRH binding to human Corticotropin releasing factor receptor 1.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCorticotropin-releasing factor receptor 1(Homo sapiens (Human))
The University Of Wollongong

Curated by ChEMBL
LigandPNGBDBM50054248(2,5-Dimethyl-N,N-dipropyl-N'-(2,4,6-trichloro-phen...)
Affinity DataKi:  2.5nMAssay Description:Inhibition of [125I]-CRH binding to human Corticotropin releasing factor receptor 1.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCorticotropin-releasing factor receptor 1(Homo sapiens (Human))
The University Of Wollongong

Curated by ChEMBL
LigandPNGBDBM50054253(CHEMBL77716 | N-Cyclopropylmethyl-5-ethyl-2-methyl...)
Affinity DataKi:  3.80nMAssay Description:Inhibition of [125I]-CRH binding to human Corticotropin releasing factor receptor 1.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent dopamine transporter(Homo sapiens (Human))
The University Of Newcastle

Curated by ChEMBL
LigandPNGBDBM50005534(1-(1-(benzo[b]thiophen-2-yl)cyclohexyl)piperidine ...)
Affinity DataKi:  6.20nMAssay Description:Displacement of [3H]BTCP from human recombinant dopamine transporter expressed in CHO cells after 120 mins by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMuscarinic acetylcholine receptor M1(Homo sapiens (Human))
The University Of Newcastle

Curated by ChEMBL
LigandPNGBDBM39341(11-[(4-methylpiperazin-1-yl)acetyl]-5,11-dihydro-6...)
Affinity DataKi:  24nMAssay Description:Displacement of [3H]pirenzepine from human recombinant Muscarinic acetylcholine receptor M1 expressed in CHO cells after 60 mins by scintillation cou...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCorticotropin-releasing factor receptor 1(Homo sapiens (Human))
The University Of Wollongong

Curated by ChEMBL
LigandPNGBDBM50054225(CHEMBL306618 | N-Cyclopropylmethyl-6-methyl-N-prop...)
Affinity DataKi:  57nMAssay Description:Inhibition of [125I]-CRH binding to human Corticotropin releasing factor receptor 1.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 6(Homo sapiens (Human))
The University Of Newcastle

Curated by ChEMBL
LigandPNGBDBM10755(14C-5-hydroxy tryptamine creatinine disulfate | 2-...)
Affinity DataKi:  61nMAssay Description:Displacement of [3H]LSD from human recombinant 5-HT6 receptor expressed in CHO cells after 120 mins by scintillation countingMore data for this Ligand-Target Pair
TargetCorticotropin-releasing factor receptor 1(Homo sapiens (Human))
The University Of Wollongong

Curated by ChEMBL
LigandPNGBDBM50054226(CHEMBL77391 | N,N-Diallyl-6-methyl-N'-(2,4,6-trime...)
Affinity DataKi:  115nMAssay Description:Inhibition of [125I]-CRH binding to human Corticotropin releasing factor receptor 1.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCorticotropin-releasing factor receptor 1(Homo sapiens (Human))
The University Of Wollongong

Curated by ChEMBL
LigandPNGBDBM50054230(6-Methyl-N,N-dipropyl-N'-(2,4,6-trimethyl-phenyl)-...)
Affinity DataKi:  130nMAssay Description:Inhibition of [125I]-CRH binding to human Corticotropin releasing factor receptor 1.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 5A(Homo sapiens (Human))
The University Of Newcastle

Curated by ChEMBL
LigandPNGBDBM10755(14C-5-hydroxy tryptamine creatinine disulfate | 2-...)
Affinity DataKi:  130nMAssay Description:Displacement of [3H]LSD from human recombinant 5-HT5a receptor in HEK293 cells after 120 mins by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCorticotropin-releasing factor receptor 1(Homo sapiens (Human))
The University Of Wollongong

Curated by ChEMBL
LigandPNGBDBM50054246(CHEMBL77006 | N-Cyclopropylmethyl-2-methyl-N-propy...)
Affinity DataKi:  253nMAssay Description:Inhibition of [125I]-CRH binding to human Corticotropin releasing factor receptor 1.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCorticotropin-releasing factor receptor 1(Homo sapiens (Human))
The University Of Wollongong

Curated by ChEMBL
LigandPNGBDBM50054246(CHEMBL77006 | N-Cyclopropylmethyl-2-methyl-N-propy...)
Affinity DataKi:  253nMAssay Description:Inhibition of [125I]-CRH binding to human Corticotropin releasing factor receptor 1.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCorticotropin-releasing factor receptor 1(Homo sapiens (Human))
The University Of Wollongong

Curated by ChEMBL
LigandPNGBDBM50054221(CHEMBL419636 | N,N-Dibutyl-6-methyl-N'-(2,4,6-trim...)
Affinity DataKi:  490nMAssay Description:Inhibition of [125I]-CRH binding to human Corticotropin releasing factor receptor 1.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCorticotropin-releasing factor receptor 1(Homo sapiens (Human))
The University Of Wollongong

Curated by ChEMBL
LigandPNGBDBM50054216(CHEMBL307419 | N-Benzyl-6-methyl-N-propyl-N'-(2,4,...)
Affinity DataKi:  490nMAssay Description:Inhibition of [125I]-CRH binding to human Corticotropin releasing factor receptor 1.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H2 receptor(Homo sapiens (Human))
The University Of Newcastle

Curated by ChEMBL
LigandPNGBDBM181119(US9138393, Cimetidine | US9144538, Cimetidine)
Affinity DataKi:  490nMAssay Description:Displacement of [125I]APT from human recombinant histamine H2 receptor expressed in CHO cells after 120 mins by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A1(Rattus norvegicus (rat))
Griffith University

Curated by ChEMBL
LigandPNGBDBM50004713((R)-2-Benzyl-7-phenyl-5-propoxy-2,7-dihydro-3H-imi...)
Affinity DataKi:  620nMAssay Description:Binding affinity for rat brain Adenosine A1 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCorticotropin-releasing factor receptor 1(Homo sapiens (Human))
The University Of Wollongong

Curated by ChEMBL
LigandPNGBDBM50054239(CHEMBL78035 | [4-(3,6-Dihydro-2H-pyridin-1-yl)-6-m...)
Affinity DataKi:  1.05E+3nMAssay Description:Inhibition of [125I]-CRH binding to human Corticotropin releasing factor receptor 1.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCorticotropin-releasing factor receptor 1(Homo sapiens (Human))
The University Of Wollongong

Curated by ChEMBL
LigandPNGBDBM50054219(CHEMBL305671 | N-Benzyl-N-butyl-6-methyl-N'-(2,4,6...)
Affinity DataKi:  1.05E+3nMAssay Description:Inhibition of [125I]-CRH binding to human Corticotropin releasing factor receptor 1.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCorticotropin-releasing factor receptor 1(Homo sapiens (Human))
The University Of Wollongong

Curated by ChEMBL
LigandPNGBDBM50054255(CHEMBL80806 | N-Cyclopropylmethyl-2-methyl-N-propy...)
Affinity DataKi:  1.39E+3nMAssay Description:Inhibition of [125I]-CRH binding to human Corticotropin releasing factor receptor 1.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCorticotropin-releasing factor receptor 1(Homo sapiens (Human))
The University Of Wollongong

Curated by ChEMBL
LigandPNGBDBM50054223(CHEMBL307871 | N-Benzyl-N-ethyl-6-methyl-N'-(2,4,6...)
Affinity DataKi:  1.47E+3nMAssay Description:Inhibition of [125I]-CRH binding to human Corticotropin releasing factor receptor 1.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A2a(Rattus norvegicus (rat))
Griffith University

Curated by ChEMBL
LigandPNGBDBM50004721((S)-8-Benzyl-3-phenyl-5-propoxy-7,8-dihydro-3H-imi...)
Affinity DataKi:  1.60E+3nMAssay Description:Binding affinity against Adenosine A2a receptor from rat striataMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCorticotropin-releasing factor receptor 1(Homo sapiens (Human))
The University Of Wollongong

Curated by ChEMBL
LigandPNGBDBM50054241(6-Methyl-N-(4-trifluoromethyl-benzyl)-N'-(2,4,6-tr...)
Affinity DataKi:  1.69E+3nMAssay Description:Inhibition of [125I]-CRH binding to human Corticotropin releasing factor receptor 1.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCorticotropin-releasing factor receptor 1(Homo sapiens (Human))
The University Of Wollongong

Curated by ChEMBL
LigandPNGBDBM50054234(6,N-Dimethyl-N-phenethyl-N'-(2,4,6-trimethyl-pheny...)
Affinity DataKi:  2.10E+3nMAssay Description:Inhibition of [125I]-CRH binding to human Corticotropin releasing factor receptor 1.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A1(Rattus norvegicus (rat))
Griffith University

Curated by ChEMBL
LigandPNGBDBM50366576(CHEMBL609546)
Affinity DataKi:  2.23E+3nMAssay Description:Binding affinity for rat brain Adenosine A1 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A1(Rattus norvegicus (rat))
Griffith University

Curated by ChEMBL
LigandPNGBDBM50366578(CHEMBL609547)
Affinity DataKi:  2.99E+3nMAssay Description:Binding affinity for rat brain Adenosine A1 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A1(Rattus norvegicus (rat))
Griffith University

Curated by ChEMBL
LigandPNGBDBM50004722((R)-8-Benzyl-3-phenyl-5-propoxy-7,8-dihydro-3H-imi...)
Affinity DataKi:  3.20E+3nMAssay Description:Binding affinity for rat brain Adenosine A1 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A2a(Rattus norvegicus (rat))
Griffith University

Curated by ChEMBL
LigandPNGBDBM50004714((S)-2-Benzyl-7-phenyl-5-propoxy-2,7-dihydro-3H-imi...)
Affinity DataKi:  3.30E+3nMAssay Description:Binding affinity against Adenosine A2a receptor from rat striataMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A1(Rattus norvegicus (rat))
Griffith University

Curated by ChEMBL
LigandPNGBDBM50366573(CHEMBL607912)
Affinity DataKi:  3.82E+3nMAssay Description:Binding affinity for rat brain Adenosine A1 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A1(Rattus norvegicus (rat))
Griffith University

Curated by ChEMBL
LigandPNGBDBM50366572(CHEMBL607911)
Affinity DataKi:  4.54E+3nMAssay Description:Binding affinity for rat brain Adenosine A1 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A1(Rattus norvegicus (rat))
Griffith University

Curated by ChEMBL
LigandPNGBDBM50004716((2R,3R)-2-Methyl-3,7-diphenyl-5-propoxy-2,7-dihydr...)
Affinity DataKi:  7.40E+3nMAssay Description:Binding affinity for rat brain Adenosine A1 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCorticotropin-releasing factor receptor 1(Homo sapiens (Human))
The University Of Wollongong

Curated by ChEMBL
LigandPNGBDBM50078345(CHEMBL309789 | N-Cyclopropylmethyl-6-methyl-N-prop...)
Affinity DataKi:  8.00E+3nMAssay Description:Inhibition of [125I]-CRH binding to human Corticotropin releasing factor receptor 1.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A1(Rattus norvegicus (rat))
Griffith University

Curated by ChEMBL
LigandPNGBDBM50004721((S)-8-Benzyl-3-phenyl-5-propoxy-7,8-dihydro-3H-imi...)
Affinity DataKi:  9.00E+3nMAssay Description:Binding affinity for rat brain Adenosine A1 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A1(Rattus norvegicus (rat))
Griffith University

Curated by ChEMBL
LigandPNGBDBM50004714((S)-2-Benzyl-7-phenyl-5-propoxy-2,7-dihydro-3H-imi...)
Affinity DataKi:  9.40E+3nMAssay Description:Binding affinity for rat brain Adenosine A1 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCorticotropin-releasing factor receptor 1(Homo sapiens (Human))
The University Of Wollongong

Curated by ChEMBL
LigandPNGBDBM50054235(CHEMBL78203 | N-Cyclopropylmethyl-6-ethyl-N-propyl...)
Affinity DataKi: >1.00E+4nMAssay Description:Inhibition of [125I]-CRH binding to human Corticotropin releasing factor receptor 1.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A2a(Rattus norvegicus (rat))
Griffith University

Curated by ChEMBL
LigandPNGBDBM50004716((2R,3R)-2-Methyl-3,7-diphenyl-5-propoxy-2,7-dihydr...)
Affinity DataKi:  1.10E+4nMAssay Description:Binding affinity against Adenosine A2a receptor from rat striataMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A1(Rattus norvegicus (rat))
Griffith University

Curated by ChEMBL
LigandPNGBDBM50366579(CHEMBL608068)
Affinity DataKi:  1.12E+4nMAssay Description:Binding affinity for rat brain Adenosine A1 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A1(Rattus norvegicus (rat))
Griffith University

Curated by ChEMBL
LigandPNGBDBM50366577(CHEMBL609247)
Affinity DataKi:  1.26E+4nMAssay Description:Binding affinity for rat brain Adenosine A1 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A2a(Rattus norvegicus (rat))
Griffith University

Curated by ChEMBL
LigandPNGBDBM50366576(CHEMBL609546)
Affinity DataKi:  1.35E+4nMAssay Description:Binding affinity against Adenosine A2a receptor from rat striataMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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