Reaction Details Report a problem with these data
Target
Histone deacetylase 2
Ligand
BDBM50398716
Substrate
n/a
Meas. Tech.
ChEMBL_1897698 (CHEMBL4399733)
Ki
1250±n/a nM
Citation
 Pflieger, M; Hamacher, A; Öz, T; Horstick-Muche, N; Boesen, B; Schrenk, C; Kassack, MU; Kurz, T Novel ?,?-unsaturated hydroxamic acid derivatives overcome cisplatin resistance. Bioorg Med Chem 27:0 (2019) [PubMed]  Article 
Target
Name:
Histone deacetylase 2
Synonyms:
Cereblon/Histone deacetylase 2 | HD2 | HDAC2 | HDAC2_HUMAN | Histone deacetylase 2 (HDAC2) | Human HDAC2
Type:
Chromatin regulator; hydrolase; repressor
Mol. Mass.:
55356.54
Organism:
Homo sapiens (Human)
Description:
Q92769
Residue:
488
Sequence:
MAYSQGGGKKKVCYYYDGDIGNYYYGQGHPMKPHRIRMTHNLLLNYGLYRKMEIYRPHKATAEEMTKYHSDEYIKFLRSIRPDNMSEYSKQMQRFNVGEDCPVFDGLFEFCQLSTGGSVAGAVKLNRQQTDMAVNWAGGLHHAKKSEASGFCYVNDIVLAILELLKYHQRVLYIDIDIHHGDGVEEAFYTTDRVMTVSFHKYGEYFPGTGDLRDIGAGKGKYYAVNFPMRDGIDDESYGQIFKPIISKVMEMYQPSAVVLQCGADSLSGDRLGCFNLTVKGHAKCVEVVKTFNLPLLMLGGGGYTIRNVARCWTYETAVALDCEIPNELPYNDYFEYFGPDFKLHISPSNMTNQNTPEYMEKIKQRLFENLRMLPHAPGVQMQAIPEDAVHEDSGDEDGEDPDKRISIRASDKRIACDEEFSDSEDEGEGGRRNVADHKKGAKKARIEEDKKETEDKKTDVKEEDKSKDNSGEKTDTKGTKSEQLSNP
  
Inhibitor
Name:
BDBM50398716
Synonyms:
CHEMBL2179618 | US10227295, Compound 5g | US9409858, 5g | US9751832, Compound 5g | US9956192, Compound 5g
Type:
Small organic molecule
Emp. Form.:
C19H23N3O3
Mol. Mass.:
341.4042
SMILES:
CCCCN(Cc1ccc(cc1)C(=O)NO)C(=O)Nc1ccccc1
Structure:
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