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Target
Cysteinyl leukotriene receptor 1
Ligand
BDBM50081533
Substrate
n/a
Meas. Tech.
ChEMBL_52384 (CHEMBL663216)
Ki
0.400000±n/a nM
Citation
 Chambers, RJ; Marfat, A; Antognoli, GW; Cheng, JB; Damon, DB; Kuperman, AV; Liston, TC; Mebus, C; Pillar, JS; Shirley, JT; Watson, JW Discovery of CP-199,330 and CP-199,331: two potent and orally efficacious cysteinyl LT1 receptor antagonists devoid of liver toxicity. Bioorg Med Chem Lett 9:2773-8 (1999) [PubMed]  Article 
Target
Name:
Cysteinyl leukotriene receptor 1
Synonyms:
CLTR1_CAVPO | CYSLTR1
Type:
Enzyme Catalytic Domain
Mol. Mass.:
39007.58
Organism:
GUINEA PIG
Description:
Leukotriene D4 0 GUINEA PIG::Q2NNR5
Residue:
340
Sequence:
MDETGNPTIPPASNNTCYDSIDDFRNQVYSTLYSMISVVGFFGNGFVLYVLVKTYHEKSAFQVYMINLAVADLLCVCTLPLRVAYYVHKGIWLFGDFLCRLSTYALYVNLYCSIFFMTAMSFFRCVAIVFPVQNISLVTQKKARLVCIAIWMFVILTSSPFLMANTYKDEKNNTKCFEPPQDNQAKNYVLILHYVSLFIGFIIPFITIIVCYTMIIFTLLKSSMKKNLSSRKRAIGMIIVVTAAFLVSFMPYHIQRTIHLHFLHNKTKPCDSILRMQKSVVITLSLAASNCCFDPLLYFFSGGNFRRRLSTIRKYSLSSMTYIPKKKTSLPQKGKDICKE
  
Inhibitor
Name:
BDBM50081533
Synonyms:
CHEMBL96224 | CP-199331 | N-{3-[(3R,4R)-6-(5,6-Difluoro-benzothiazol-2-ylmethoxy)-4-hydroxy-chroman-3-ylmethyl]-4-methoxy-phenyl}-C,C,C-trifluoro-methanesulfonamide
Type:
Small organic molecule
Emp. Form.:
C26H21F5N2O6S2
Mol. Mass.:
616.577
SMILES:
COc1ccc(NS(=O)(=O)C(F)(F)F)cc1C[C@@H]1COc2ccc(OCc3nc4cc(F)c(F)cc4s3)cc2[C@@H]1O
Structure:
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