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Target
Polyphenol oxidase 2
Ligand
BDBM50526625
Substrate
n/a
Meas. Tech.
ChEMBL_1900393 (CHEMBL4402615)
Ki
1700±n/a nM
Citation
 Kim, JY; Kim, JY; Jenis, J; Li, ZP; Ban, YJ; Baiseitova, A; Park, KH Tyrosinase inhibitory study of flavonolignans from the seeds of Silybum marianum (Milk thistle). Bioorg Med Chem 27:2499-2507 (2019) [PubMed]  Article 
Target
Name:
Polyphenol oxidase 2
Synonyms:
Monophenol monooxygenase | Monophenol oxidase | PPO2 | PPO2_AGABI | Tyrosinase
Type:
Protein
Mol. Mass.:
63923.66
Organism:
Agaricus bisporus (Common mushroom)
Description:
O42713
Residue:
556
Sequence:
MSLIATVGPTGGVKNRLNIVDFVKNEKFFTLYVRSLELLQAKEQHDYSSFFQLAGIHGLPFTEWAKERPSMNLYKAGYCTHGQVLFPTWHRTYLSVLEQILQGAAIEVAKKFTSNQTDWVQAAQDLRQPYWDWGFELMPPDEVIKNEEVNITNYDGKKISVKNPILRYHFHPIDPSFKPYGDFATWRTTVRNPDRNRREDIPGLIKKMRLEEGQIREKTYNMLKFNDAWERFSNHGISDDQHANSLESVHDDIHVMVGYGKIEGHMDHPFFAAFDPIFWLHHTNVDRLLSLWKAINPDVWVTSGRNRDGTMGIAPNAQINSETPLEPFYQSGDKVWTSASLADTARLGYSYPDFDKLVGGTKELIRDAIDDLIDERYGSKPSSGARNTAFDLLADFKGITKEHKEDLKMYDWTIHVAFKKFELKESFSLLFYFASDGGDYDQENCFVGSINAFRGTAPETCANCQDNENLIQEGFIHLNHYLARDLESFEPQDVHKFLKEKGLSYKLYSRGDKPLTSLSVKIEGRPLHLPPGEHRPKYDHTQARVVFDDVAVHVIN
  
Inhibitor
Name:
BDBM50526625
Synonyms:
CHEMBL4592595
Type:
Small organic molecule
Emp. Form.:
C25H22O10
Mol. Mass.:
482.4362
SMILES:
[H][C@]12CO[C@]3(O)C1C(=CC([C@@H]2c1ccc(O)c(OC)c1)C3=O)[C@H]1Oc2cc(O)cc(O)c2C(=O)[C@@H]1O |r,c:8,TLB:21:20:7.8:10.1,11:10:7.8:20.4,THB:3:4:7.8:10.1,2:1:7.8:20.4|
Structure:
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