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Target
Beta-1 adrenergic receptor
Ligand
BDBM25751
Substrate
n/a
Meas. Tech.
ChEMBL_1900545 (CHEMBL4402767)
Ki
5.3±n/a nM
Citation
 Schwalbe, T; Huebner, H; Gmeiner, P Development of covalent antagonists for ?1- and ?2-adrenergic receptors. Bioorg Med Chem 27:2959-2971 (2019) [PubMed]  Article 
Target
Name:
Beta-1 adrenergic receptor
Synonyms:
ADRB1_MOUSE | Adrb1 | Adrb1r | Beta-1 adrenergic recepto | Beta-1 adrenergic receptor | Beta-1 adrenoceptor | Beta-1 adrenoreceptor
Type:
PROTEIN
Mol. Mass.:
50507.75
Organism:
Mus musculus
Description:
ChEMBL_105090
Residue:
466
Sequence:
MGAGALALGASEPCNLSSAAPLPDGAATAARLLVLASPPASLLPPASEGSAPLSQQWTAGMGLLLALIVLLIVVGNVLVIVAIAKTPRLQTLTNLFIMSLASADLVMGLLVVPFGATIVVWGRWEYGSFFCELWTSVDVLCVTASIETLCVIALDRYLAITSPFRYQSLLTRARARALVCTVWAISALVSFLPILMHWWRAESDEARRCYNDPKCCDFVTNRAYAIASSVVSFYVPLCIMAFVYLRVFREAQKQVKKIDSCERRFLGGPARPPSPEPSPSPGPPRPADSLANGRSSKRRPSRLVALREQKALKTLGIIMGVFTLCWLPFFLANVVKAFHRDLVPDRLFVFFNWLGYANSAFNPIIYCRSPDFRKAFQRLLCCARRAACRRRAAHGDRPRASGCLARAGPPPSPGAPSDDDDDDAGTTPPARLLEPWTGCNGGTTTVDSDSSLDEPGRQGFSSESKV
  
Inhibitor
Name:
BDBM25751
Synonyms:
Bisoprolol | Bisoprolol fumarate | Concor | [2-hydroxy-3-(4-{[2-(propan-2-yloxy)ethoxy]methyl}phenoxy)propyl](propan-2-yl)amine
Type:
Small organic molecule
Emp. Form.:
C18H31NO4
Mol. Mass.:
325.443
SMILES:
CC(C)NCC(O)COc1ccc(COCCOC(C)C)cc1
Structure:
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