Reaction Details Report a problem with these data
Target
Gamma-aminobutyric acid receptor subunit alpha-5
Ligand
BDBM50459892
Substrate
n/a
Meas. Tech.
ChEMBL_1901498 (CHEMBL4403720)
Ki
55±n/a nM
Citation
 Maramai, S; Benchekroun, M; Ward, SE; Atack, JR Subtype Selective ?-Aminobutyric Acid Type A Receptor (GABA J Med Chem 63:3425-3446 (2020) [PubMed]  Article 
Target
Name:
Gamma-aminobutyric acid receptor subunit alpha-5
Synonyms:
GABA receptor alpha-5 subunit | GABA(A) receptor subunit alpha-5 (GABAAa5) | GABRA5 | GBRA5_HUMAN | Gamma-aminobutyric acid receptor subunit alpha-5 (GABA(A)) | Gamma-aminobutyric acid receptor subunit alpha-5 (GABAA)
Type:
Enzyme
Mol. Mass.:
52160.59
Organism:
Homo sapiens (Human)
Description:
P31644
Residue:
462
Sequence:
MDNGMFSGFIMIKNLLLFCISMNLSSHFGFSQMPTSSVKDETNDNITIFTRILDGLLDGYDNRLRPGLGERITQVRTDIYVTSFGPVSDTEMEYTIDVFFRQSWKDERLRFKGPMQRLPLNNLLASKIWTPDTFFHNGKKSIAHNMTTPNKLLRLEDDGTLLYTMRLTISAECPMQLEDFPMDAHACPLKFGSYAYPNSEVVYVWTNGSTKSVVVAEDGSRLNQYHLMGQTVGTENISTSTGEYTIMTAHFHLKRKIGYFVIQTYLPCIMTVILSQVSFWLNRESVPARTVFGVTTVLTMTTLSISARNSLPKVAYATAMDWFIAVCYAFVFSALIEFATVNYFTKRGWAWDGKKALEAAKIKKKREVILNKSTNAFTTGKMSHPPNIPKEQTPAGTSNTTSVSVKPSEEKTSESKKTYNSISKIDKMSRIVFPVLFGTFNLVYWATYLNREPVIKGAASPK
  
Inhibitor
Name:
BDBM50459892
Synonyms:
CHEMBL4228824
Type:
Small organic molecule
Emp. Form.:
C22H17FN4O
Mol. Mass.:
372.395
SMILES:
CNC(=O)c1ncn-2c1[C@@H](C)N=C(c1ccccc1F)c1cc(ccc-21)C#C |r,t:12|
Structure:
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