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Target
ATP-dependent Clp protease proteolytic subunit
Ligand
BDBM50527101
Substrate
n/a
Meas. Tech.
ChEMBL_1902065 (CHEMBL4404287)
EC50
2600±n/a nM
Citation
 Ju, Y; He, L; Zhou, Y; Yang, T; Sun, K; Song, R; Yang, Y; Li, C; Sang, Z; Bao, R; Luo, Y Discovery of Novel Peptidomimetic Boronate ClpP Inhibitors with Noncanonical Enzyme Mechanism as Potent Virulence Blockers  J Med Chem 63:3104-3119 (2020) [PubMed]  Article 
Target
Name:
ATP-dependent Clp protease proteolytic subunit
Synonyms:
CLPP_STAA8 | Endopeptidase Clp | clpP
Type:
PROTEIN
Mol. Mass.:
21508.79
Organism:
Staphylococcus aureus (strain NCTC 8325)
Description:
ChEMBL_796596
Residue:
195
Sequence:
MNLIPTVIETTNRGERAYDIYSRLLKDRIIMLGSQIDDNVANSIVSQLLFLQAQDSEKDIYLYINSPGGSVTAGFAIYDTIQHIKPDVQTICIGMAASMGSFLLAAGAKGKRFALPNAEVMIHQPLGGAQGQATEIEIAANHILKTREKLNRILSERTGQSIEKIQKDTDRDNFLTAEEAKEYGLIDEVMVPETK
  
Inhibitor
Name:
BDBM50527101
Synonyms:
CHEMBL4540126
Type:
Small organic molecule
Emp. Form.:
C29H40BN3O4
Mol. Mass.:
505.457
SMILES:
CC(C)C[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)C(C)c1ccc(CC(C)C)cc1)B(O)O |r|
Structure:
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