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Target
ATP-dependent Clp protease proteolytic subunit
Ligand
BDBM50527102
Substrate
n/a
Meas. Tech.
ChEMBL_1902065 (CHEMBL4404287)
EC50
3300±n/a nM
Citation
 Ju, Y; He, L; Zhou, Y; Yang, T; Sun, K; Song, R; Yang, Y; Li, C; Sang, Z; Bao, R; Luo, Y Discovery of Novel Peptidomimetic Boronate ClpP Inhibitors with Noncanonical Enzyme Mechanism as Potent Virulence Blockers  J Med Chem 63:3104-3119 (2020) [PubMed]  Article 
Target
Name:
ATP-dependent Clp protease proteolytic subunit
Synonyms:
CLPP_STAA8 | Endopeptidase Clp | clpP
Type:
PROTEIN
Mol. Mass.:
21508.79
Organism:
Staphylococcus aureus (strain NCTC 8325)
Description:
ChEMBL_796596
Residue:
195
Sequence:
MNLIPTVIETTNRGERAYDIYSRLLKDRIIMLGSQIDDNVANSIVSQLLFLQAQDSEKDIYLYINSPGGSVTAGFAIYDTIQHIKPDVQTICIGMAASMGSFLLAAGAKGKRFALPNAEVMIHQPLGGAQGQATEIEIAANHILKTREKLNRILSERTGQSIEKIQKDTDRDNFLTAEEAKEYGLIDEVMVPETK
  
Inhibitor
Name:
BDBM50527102
Synonyms:
CHEMBL4536802
Type:
Small organic molecule
Emp. Form.:
C22H29BN2O5
Mol. Mass.:
412.287
SMILES:
COc1ccc(cc1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CC(C)C)B(O)O
Structure:
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