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Target
ATP-dependent Clp protease proteolytic subunit
Ligand
BDBM50462621
Substrate
n/a
Meas. Tech.
ChEMBL_1902070 (CHEMBL4404292)
EC50
19900±n/a nM
Citation
 Ju, Y; He, L; Zhou, Y; Yang, T; Sun, K; Song, R; Yang, Y; Li, C; Sang, Z; Bao, R; Luo, Y Discovery of Novel Peptidomimetic Boronate ClpP Inhibitors with Noncanonical Enzyme Mechanism as Potent Virulence Blockers  J Med Chem 63:3104-3119 (2020) [PubMed]  Article 
Target
Name:
ATP-dependent Clp protease proteolytic subunit
Synonyms:
CLPP_STAA8 | Endopeptidase Clp | clpP
Type:
PROTEIN
Mol. Mass.:
21508.79
Organism:
Staphylococcus aureus (strain NCTC 8325)
Description:
ChEMBL_796596
Residue:
195
Sequence:
MNLIPTVIETTNRGERAYDIYSRLLKDRIIMLGSQIDDNVANSIVSQLLFLQAQDSEKDIYLYINSPGGSVTAGFAIYDTIQHIKPDVQTICIGMAASMGSFLLAAGAKGKRFALPNAEVMIHQPLGGAQGQATEIEIAANHILKTREKLNRILSERTGQSIEKIQKDTDRDNFLTAEEAKEYGLIDEVMVPETK
  
Inhibitor
Name:
BDBM50462621
Synonyms:
CHEMBL1813256 | MLN-9708 | US11542283, Compound MLN-9708
Type:
Small organic molecule
Emp. Form.:
C20H23BCl2N2O9
Mol. Mass.:
517.122
SMILES:
CC(C)C[C@H](NC(=O)CNC(=O)c1cc(Cl)ccc1Cl)B1OC(=O)CC(CC(O)=O)(O1)C(O)=O |r|
Structure:
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