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Target
ATP-dependent Clp protease proteolytic subunit
Ligand
BDBM50069989
Substrate
n/a
Meas. Tech.
ChEMBL_1902065 (CHEMBL4404287)
EC50
23500±n/a nM
Citation
 Ju, Y; He, L; Zhou, Y; Yang, T; Sun, K; Song, R; Yang, Y; Li, C; Sang, Z; Bao, R; Luo, Y Discovery of Novel Peptidomimetic Boronate ClpP Inhibitors with Noncanonical Enzyme Mechanism as Potent Virulence Blockers  J Med Chem 63:3104-3119 (2020) [PubMed]  Article 
Target
Name:
ATP-dependent Clp protease proteolytic subunit
Synonyms:
CLPP_STAA8 | Endopeptidase Clp | clpP
Type:
PROTEIN
Mol. Mass.:
21508.79
Organism:
Staphylococcus aureus (strain NCTC 8325)
Description:
ChEMBL_796596
Residue:
195
Sequence:
MNLIPTVIETTNRGERAYDIYSRLLKDRIIMLGSQIDDNVANSIVSQLLFLQAQDSEKDIYLYINSPGGSVTAGFAIYDTIQHIKPDVQTICIGMAASMGSFLLAAGAKGKRFALPNAEVMIHQPLGGAQGQATEIEIAANHILKTREKLNRILSERTGQSIEKIQKDTDRDNFLTAEEAKEYGLIDEVMVPETK
  
Inhibitor
Name:
BDBM50069989
Synonyms:
(R)-3-methyl-1-((S)-3-phenyl-2-(pyrazine-2-carboxamido)propanamido)butylboronic acid | (R)-3-methyl-1-((S)-3-phenyl-2-(pyrazine-6-carboxamido)propanamido)butylboronic acid | BORTEZOMIB | CHEMBL325041 | Dipeptidyl boronic acid derivative | LDP-341 | N-[(1R)-1-(DIHYDROXYBORYL)-3-METHYLBUTYL]-N-(PYRAZIN-2-YLCARBONYL)-L-PHENYLALANINAMIDE | PS-341 | Peptidyl boronic acid derivative | US11542283, Compound Velcade | Velcade | cid_387447
Type:
Small organic molecule
Emp. Form.:
C19H25BN4O4
Mol. Mass.:
384.237
SMILES:
CC(C)C[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)c1cnccn1)B(O)O |r|
Structure:
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