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Target
Retinoic acid receptor RXR-gamma
Ligand
BDBM50083048
Substrate
n/a
Meas. Tech.
ChEMBL_197239 (CHEMBL803361)
Kd
1400±n/a nM
Citation
 Simoni, D; Invidiata, FP; Rondanin, R; Grimaudo, S; Cannizzo, G; Barbusca, E; Porretto, F; D'Alessandro, N; Tolomeo, M Structure-activity relationship studies of novel heteroretinoids: induction of apoptosis in the HL-60 cell line by a novel isoxazole-containing heteroretinoid. J Med Chem 42:4961-9 (2000) [PubMed]  Article 
Target
Name:
Retinoic acid receptor RXR-gamma
Synonyms:
NR2B3 | Nuclear receptor subfamily 2 group B member 3 | RXRG | RXRG_HUMAN | Retinoic acid receptor RXR-gamma | Retinoid X receptor gamma | Retinoid X receptor gamma/retinoic acid receptor alpha
Type:
PROTEIN
Mol. Mass.:
50878.26
Organism:
Homo sapiens (Human)
Description:
ChEMBL_197216
Residue:
463
Sequence:
MYGNYSHFMKFPAGYGGSPGHTGSTSMSPSAALSTGKPMDSHPSYTDTPVSAPRTLSAVGTPLNALGSPYRVITSAMGPPSGALAAPPGINLVAPPSSQLNVVNSVSSSEDIKPLPGLPGIGNMNYPSTSPGSLVKHICAICGDRSSGKHYGVYSCEGCKGFFKRTIRKDLIYTCRDNKDCLIDKRQRNRCQYCRYQKCLVMGMKREAVQEERQRSRERAESEAECATSGHEDMPVERILEAELAVEPKTESYGDMNMENSTNDPVTNICHAADKQLFTLVEWAKRIPHFSDLTLEDQVILLRAGWNELLIASFSHRSVSVQDGILLATGLHVHRSSAHSAGVGSIFDRVLTELVSKMKDMQMDKSELGCLRAIVLFNPDAKGLSNPSEVETLREKVYATLEAYTKQKYPEQPGRFAKLLLRLPALRSIGLKCLEHLFFFKLIGDTPIDTFLMEMLETPLQIT
  
Inhibitor
Name:
BDBM50083048
Synonyms:
5-[(E)-2-(5,5,8,8-Tetramethyl-5,6,7,8-tetrahydro-naphthalen-2-yl)-propenyl]-isoxazole-3-carboxylic acid | CHEMBL357015
Type:
Small organic molecule
Emp. Form.:
C21H25NO3
Mol. Mass.:
339.4281
SMILES:
C\C(=C/c1cc(no1)C(O)=O)c1ccc2c(c1)C(C)(C)CCC2(C)C
Structure:
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