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Target
Protein arginine N-methyltransferase 7
Ligand
BDBM50529897
Substrate
n/a
Meas. Tech.
ChEMBL_1910930 (CHEMBL4413376)
IC50
>100000±n/a nM
Citation
 Shao, J; Zhu, K; Du, D; Zhang, Y; Tao, H; Chen, Z; Jiang, H; Chen, K; Luo, C; Duan, W Discovery of 2-substituted-N-(3-(3,4-dihydroisoquinolin-2(1H)-yl)-2-hydroxypropyl)-1,2,3,4-tetrahydroisoquinoline-6-carboxamide as potent and selective protein arginine methyltransferases 5 inhibitors: Design, synthesis and biological evaluation. Eur J Med Chem 164:317-333 (2019) [PubMed]  Article 
Target
Name:
Protein arginine N-methyltransferase 7
Synonyms:
ANM7_HUMAN | Histone-arginine N-methyltransferase PRMT7 | KIAA1933 | PRMT7 | Protein arginine N-methyltransferase 7 | Protein arginine methyltransferase 7 (PRMT7) | [Myelin basic protein]-arginine N-methyltransferase PRMT7
Type:
Enzyme
Mol. Mass.:
78440.77
Organism:
Homo sapiens (Human)
Description:
Q9NVM4
Residue:
692
Sequence:
MKIFCSRANPTTGSVEWLEEDEHYDYHQEIARSSYADMLHDKDRNVKYYQGIRAAVSRVKDRGQKALVLDIGTGTGLLSMMAVTAGADFCYAIEVFKPMADAAVKIVEKNGFSDKIKVINKHSTEVTVGPEGDMPCRANILVTELFDTELIGEGALPSYEHAHRHLVEENCEAVPHRATVYAQLVESGRMWSWNKLFPIHVQTSLGEQVIVPPVDVESCPGAPSVCDIQLNQVSPADFTVLSDVLPMFSIDFSKQVSSSAACHSRRFEPLTSGRAQVVLSWWDIEMDPEGKIKCTMAPFWAHSDPEEMQWRDHWMQCVYFLPQEEPVVQGSALYLVAHHDDYCVWYSLQRTSPEKNERVRQMRPVCDCQAHLLWNRPRFGEINDQDRTDRYVQALRTVLKPDSVCLCVSDGSLLSVLAHHLGVEQVFTVESSAASHKLLRKIFKANHLEDKINIIEKRPELLTNEDLQGRKVSLLLGEPFFTTSLLPWHNLYFWYVRTAVDQHLGPGAMVMPQAASLHAVVVEFRDLWRIRSPCGDCEGFDVHIMDDMIKRALDFRESREAEPHPLWEYPCRSLSEPWQILTFDFQQPVPLQPLCAEGTVELRRPGQSHAAVLWMEYHLTPECTLSTGLLEPADPEGGCCWNPHCKQAVYFFSPAPDPRALLGGPRTVSYAVEFHPDTGDIIMEFRHADTPD
  
Inhibitor
Name:
BDBM50529897
Synonyms:
CHEMBL4468383
Type:
Small organic molecule
Emp. Form.:
C29H30BrN3O3
Mol. Mass.:
548.471
SMILES:
O[C@@H](CNC(=O)c1ccc2CN(CCc2c1)C(=O)c1ccc(Br)cc1)CN1CCc2ccccc2C1 |r|
Structure:
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