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Target
RNA-directed RNA polymerase
Ligand
BDBM50271224
Substrate
n/a
Meas. Tech.
ChEMBL_1911276 (CHEMBL4413722)
IC50
63±n/a nM
Citation
 Mengshetti, S; Zhou, L; Sari, O; De Schutter, C; Zhang, H; Cho, JH; Tao, S; Bassit, LC; Verma, K; Domaoal, RA; Ehteshami, M; Jiang, Y; Ovadia, R; Kasthuri, M; Ollinger Russell, O; McBrayer, T; Whitaker, T; Pattassery, J; Pascual, ML; Uher, L; Lin, BY; Lee, S; Amblard, F; Coats, SJ; Schinazi, RF Discovery of a Series of 2'-?-Fluoro,2'-?-bromo-ribonucleosides and Their Phosphoramidate Prodrugs as Potent Pan-Genotypic Inhibitors of Hepatitis C Virus. J Med Chem 62:1859-1874 (2019) [PubMed]  Article 
Target
Name:
RNA-directed RNA polymerase
Synonyms:
Hepatitis C virus NS5B RNA-dependent RNA polymerase | NS5B protein
Type:
Protein
Mol. Mass.:
25173.95
Organism:
Hepatitis C virus
Description:
Q8JXU8
Residue:
229
Sequence:
RTEEAIYQCCDLDPQARVAIRSLTERLYVGGPLTNSRGENCGYRRRASGVLTTSCGNTLTCYIKAQAACRAAGRQDCTMLVCGDDLVVICESAGVQEDAASLRAFTEAMTRYSAPPGDPPQPEYDLELITSCSSNVSVAHDGAGKRVYYLTRDPTTPLARAAWETARHTPVNSWLGNIIMFAPTLWVRMIMLTHFFSVLIARDQLEQALDCEIYGACYSIEPLLPPIIQ
  
Inhibitor
Name:
BDBM50271224
Synonyms:
2'-C-Methyl-uridine-5'-triphosphate | CHEMBL521487
Type:
Small organic molecule
Emp. Form.:
C10H17N2O15P3
Mol. Mass.:
498.1677
SMILES:
C[C@@]1(O)[C@H](O)[C@@H](COP(O)(=O)OP(O)(=O)OP(O)(O)=O)O[C@H]1n1ccc(=O)[nH]c1=O |r|
Structure:
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