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Target
Neuronal acetylcholine receptor subunit alpha-7
Ligand
BDBM50530217
Substrate
n/a
Meas. Tech.
ChEMBL_1911484 (CHEMBL4413930)
EC50
48±n/a nM
Citation
 Manetti, D; Garifulina, A; Bartolucci, G; Bazzicalupi, C; Bellucci, C; Chiaramonte, N; Dei, S; Di Cesare Mannelli, L; Ghelardini, C; Gratteri, P; Spirova, E; Shelukhina, I; Teodori, E; Varani, K; Tsetlin, V; Romanelli, MN New Rigid Nicotine Analogues, Carrying a Norbornane Moiety, Are Potent Agonists of ?7 and ?3* Nicotinic Receptors. J Med Chem 62:1887-1901 (2019) [PubMed]  Article 
Target
Name:
Neuronal acetylcholine receptor subunit alpha-7
Synonyms:
ACHA7_HUMAN | CHRNA7 | Cholinergic, Nicotinic Alpha7 | NACHRA7 | Neuronal acetylcholine receptor protein alpha-7 subunit | Neuronal acetylcholine receptor subunit alpha-7 (nAChR-alpha 7) | Nicotinic acetylcholine receptor alpha-7 (alpha7 nAChR)
Type:
n/a
Mol. Mass.:
56448.33
Organism:
Homo sapiens (Human)
Description:
CHRNA7 (NACHRA7)
Residue:
502
Sequence:
MRCSPGGVWLALAASLLHVSLQGEFQRKLYKELVKNYNPLERPVANDSQPLTVYFSLSLLQIMDVDEKNQVLTTNIWLQMSWTDHYLQWNVSEYPGVKTVRFPDGQIWKPDILLYNSADERFDATFHTNVLVNSSGHCQYLPPGIFKSSCYIDVRWFPFDVQHCKLKFGSWSYGGWSLDLQMQEADISGYIPNGEWDLVGIPGKRSERFYECCKEPYPDVTFTVTMRRRTLYYGLNLLIPCVLISALALLVFLLPADSGEKISLGITVLLSLTVFMLLVAEIMPATSDSVPLIAQYFASTMIIVGLSVVVTVIVLQYHHHDPDGGKMPKWTRVILLNWCAWFLRMKRPGEDKVRPACQHKQRRCSLASVEMSAVAPPPASNGNLLYIGFRGLDGVHCVPTPDSGVVCGRMACSPTHDEHLLHGGQPPEGDPDLAKILEEVRYIANRFRCQDESEAVCSEWKFAACVVDRLCLMAFSVFTIICTIGILMSAPNFVEAVSKDFA
  
Inhibitor
Name:
BDBM50530217
Synonyms:
CHEMBL4550498
Type:
Small organic molecule
Emp. Form.:
C12H16N2
Mol. Mass.:
188.2688
SMILES:
[H][C@@]12CC[C@@]([H])(C1)[C@H]([C@@H]2N)c1cccnc1 |r,TLB:9:8:2.3:6,THB:10:7:2.3:6|
Structure:
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