Reaction Details Report a problem with these data
Target
Leukocyte surface antigen CD47
Ligand
BDBM50530415
Substrate
n/a
Meas. Tech.
ChEMBL_1912518 (CHEMBL4415101)
Kd
190±n/a nM
Citation
Denèfle, T; Pramil, E; Gómez-Morales, L; Levasseur, MD; Lardé, E; Newton, C; Herry, K; Herbi, L; Lamotte, Y; Odile, E; Ancellin, N; Grondin, P; Martinez-Torres, AC; Viviani, F; Merle-Beral, H; Lequin, O; Susin, SA; Karoyan, P Homotrimerization Approach in the Design of Thrombospondin-1 Mimetic Peptides with Improved Potency in Triggering Regulated Cell Death of Cancer Cells. J Med Chem 62:7656-7668 (2019) [PubMed] Article
More Info.:
Target
Name:
Leukocyte surface antigen CD47
Synonyms:
Antigenic surface determinant protein OA3 | CD47 | CD47_HUMAN | CD_antigen=CD47 | IAP | Integrin-associated protein | Leukocyte surface antigen CD47 | MER6 | Protein MER6
Type:
PROTEIN
Mol. Mass.:
35214.74
Organism:
Homo sapiens (Human)
Description:
ChEMBL_116544
Residue:
323
Sequence:
MWPLVAALLLGSACCGSAQLLFNKTKSVEFTFCNDTVVIPCFVTNMEAQNTTEVYVKWKFKGRDIYTFDGALNKSTVPTDFSSAKIEVSQLLKGDASLKMDKSDAVSHTGNYTCEVTELTREGETIIELKYRVVSWFSPNENILIVIFPIFAILLFWGQFGIKTLKYRSGGMDEKTIALLVAGLVITVIVIVGAILFVPGEYSLKNATGLGLIVTSTGILILLHYYVFSTAIGLTSFVIAILVIQVIAYILAVVGLSLCIAACIPMHGPLLISGLSILALAQLLGLVYMKFVASNQKTIQPPRKAVEEPLNAFKESKGMMNDE
Inhibitor
Name:
BDBM50530415
Synonyms:
CHEMBL4522427
Type:
Small organic molecule
Emp. Form.:
C234H359N61O38
Mol. Mass.:
4634.7402
SMILES:
CCCC[C@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CCCNC(N)=N)N(C)C(=O)[C@@H](CCCCN)NC(=O)CCCCn1cc(CN(Cc2cn(CCCCC(=O)N[C@H](CCCCN)C(=O)N(C)[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc3ccccc3)C(=O)N[C@@H](Cc3ccc(O)cc3)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCC)C(=O)N[C@@H](Cc3c[nH]c4ccccc34)C(=O)N[C@@H](CCCCN)C(=O)N[C@H](CCCCN)C(O)=O)nn2)Cc2cn(CCCCC(=O)N[C@H](CCCCN)C(=O)N(C)[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc3ccccc3)C(=O)N[C@@H](Cc3ccc(O)cc3)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCC)C(=O)N[C@@H](Cc3c[nH]c4ccccc34)C(=O)N[C@@H](CCCCN)C(=O)N[C@H](CCCCN)C(O)=O)nn2)nn1)C(C)C)C(C)C)C(=O)N[C@H](CN[C@@H](CCCCN)C(=O)N[C@H](CCCCN)C(O)=O)Cc1c[nH]c2ccccc12 |r|