Reaction Details Report a problem with these data
Target
Sigma non-opioid intracellular receptor 1
Ligand
BDBM50532508
Substrate
n/a
Meas. Tech.
ChEMBL_1923200 (CHEMBL4426156)
Ki
0.500000±n/a nM
Citation
 Sun, H; Shi, M; Zhang, W; Zheng, YM; Xu, YZ; Shi, JJ; Liu, T; Gunosewoyo, H; Pang, T; Gao, ZB; Yang, F; Tang, J; Yu, LF Development of Novel Alkoxyisoxazoles as Sigma-1 Receptor Antagonists with Antinociceptive Efficacy. J Med Chem 59:6329-43 (2016) [PubMed]  Article 
Target
Name:
Sigma non-opioid intracellular receptor 1
Synonyms:
Opioid receptor | Oprs1 | SGMR1_RAT | Sigma | Sigma non-opioid intracellular receptor 1 | Sigma opioid receptor | Sigma-1 | Sigmar1
Type:
Enzyme Catalytic Domain
Mol. Mass.:
25266.54
Organism:
RAT
Description:
Q9R0C9
Residue:
223
Sequence:
MPWAVGRRWAWITLFLTIVAVLIQAVWLWLGTQSFVFQREEIAQLARQYAGLDHELAFSRLIVELRRLHPGHVLPDEELQWVFVNAGGWMGAMCLLHASLSEYVLLFGTALGSHGHSGRYWAEISDTIISGTFHQWREGTTKSEVYYPGETVVHGPGEATAVEWGPNTWMVEYGRGVIPSTLAFALSDTIFSTQDFLTLFYTLRAYARGLRLELTTYLFGQDP
  
Inhibitor
Name:
BDBM50532508
Synonyms:
CHEMBL4471576
Type:
Small organic molecule
Emp. Form.:
C19H26ClFN2O3
Mol. Mass.:
384.873
SMILES:
Cl.CN(CCOc1cc(COc2cccc(F)c2)on1)C1CCCCC1
Structure:
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