Reaction Details Report a problem with these data
Target
Hexokinase-4
Ligand
BDBM50533097
Substrate
n/a
Meas. Tech.
ChEMBL_1924392 (CHEMBL4427348)
EC50
97±n/a nM
Citation
 Kohn, TJ; Du, X; Lai, S; Xiong, Y; Komorowski, R; Veniant, M; Fu, Z; Jiao, X; Pattaropong, V; Chow, D; Cardozo, M; Jin, L; Conn, M; DeWolf, WE; Kraser, CF; Hinklin, RJ; Boys, ML; Medina, JC; Houze, J; Dransfield, P; Coward, P 5-Alkyl-2-urea-Substituted Pyridines: Identification of Efficacious Glucokinase Activators with Improved Properties. ACS Med Chem Lett 7:666-70 (2016) [PubMed]  Article 
Target
Name:
Hexokinase-4
Synonyms:
GCK | Glucokinase (GCK) | Glucokinase (GK) | Glucokinase/Glucokinase regulatory protein | HK IV | HK4 | HXK4_HUMAN | Hexokinase-4 | Hexokinase-D
Type:
Enzyme
Mol. Mass.:
52175.81
Organism:
Homo sapiens (Human)
Description:
P35557
Residue:
465
Sequence:
MLDDRARMEAAKKEKVEQILAEFQLQEEDLKKVMRRMQKEMDRGLRLETHEEASVKMLPTYVRSTPEGSEVGDFLSLDLGGTNFRVMLVKVGEGEEGQWSVKTKHQMYSIPEDAMTGTAEMLFDYISECISDFLDKHQMKHKKLPLGFTFSFPVRHEDIDKGILLNWTKGFKASGAEGNNVVGLLRDAIKRRGDFEMDVVAMVNDTVATMISCYYEDHQCEVGMIVGTGCNACYMEEMQNVELVEGDEGRMCVNTEWGAFGDSGELDEFLLEYDRLVDESSANPGQQLYEKLIGGKYMGELVRLVLLRLVDENLLFHGEASEQLRTRGAFETRFVSQVESDTGDRKQIYNILSTLGLRPSTTDCDIVRRACESVSTRAAHMCSAGLAGVINRMRESRSEDVMRITVGVDGSVYKLHPSFKERFHASVRRLTPSCEITFIESEEGSGRGAALVSAVACKKACMLGQ
  
Inhibitor
Name:
BDBM50533097
Synonyms:
CHEMBL4471994
Type:
Small organic molecule
Emp. Form.:
C18H22N4O3
Mol. Mass.:
342.3923
SMILES:
CNC(=O)Nc1cc(Oc2cncc(C)c2)c(cn1)[C@@H]1CC[C@@H](O)C1 |r|
Structure:
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