Reaction Details Report a problem with these data
Target
Cyclin-dependent kinase 1
Ligand
BDBM50088909
Substrate
n/a
Meas. Tech.
ChEBML_226355
IC50
30000±n/a nM
Citation
 Missbach, M; Altmann, E; Widler, L; Susa, M; Buchdunger, E; Mett, H; Meyer, T; Green, J Substituted 5,7-diphenyl-pyrrolo[2,3d]pyrimidines: potent inhibitors of the tyrosine kinase c-Src. Bioorg Med Chem Lett 10:945-9 (2000) [PubMed]  Article 
Target
Name:
Cyclin-dependent kinase 1
Synonyms:
CDC2 | CDC28A | CDK1 | CDK1_HUMAN | CDKN1 | Cell division control protein 2 homolog | Cell division protein kinase 1 | Cyclin-dependent kinase 1 (CDK1) | P34CDC2 | p34 protein kinase
Type:
Enzyme Subunit
Mol. Mass.:
34101.08
Organism:
Homo sapiens (Human)
Description:
P06493
Residue:
297
Sequence:
MEDYTKIEKIGEGTYGVVYKGRHKTTGQVVAMKKIRLESEEEGVPSTAIREISLLKELRHPNIVSLQDVLMQDSRLYLIFEFLSMDLKKYLDSIPPGQYMDSSLVKSYLYQILQGIVFCHSRRVLHRDLKPQNLLIDDKGTIKLADFGLARAFGIPIRVYTHEVVTLWYRSPEVLLGSARYSTPVDIWSIGTIFAELATKKPLFHGDSEIDQLFRIFRALGTPNNEVWPEVESLQDYKNTFPKWKPGSLASHVKNLDENGLDLLSKMLIYDPAKRISGKMALNHPYFNDLDNQIKKM
  
Inhibitor
Name:
BDBM50088909
Synonyms:
(4-(4-amino-5-phenyl-7H-pyrrolo[2,3-d]pyrimidin-7-yl)phenyl)methanol | CHEMBL367442 | [4-(4-Amino-5-phenyl-pyrrolo[2,3-d]pyrimidin-7-yl)-phenyl]-methanol
Type:
Small organic molecule
Emp. Form.:
C19H16N4O
Mol. Mass.:
316.3565
SMILES:
Nc1ncnc2n(cc(-c3ccccc3)c12)-c1ccc(CO)cc1
Structure:
Search PDB for entries with ligand similarity: