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Target
Histamine H3 receptor
Ligand
BDBM50091373
Substrate
n/a
Meas. Tech.
ChEMBL_86898 (CHEMBL698408)
Ki
0.3±n/a nM
Citation
 Sasse, A; Sadek, B; Ligneau, X; Elz, S; Pertz, HH; Luger, P; Ganellin, CR; Arrang, JM; Schwartz, JC; Schunack, W; Stark, H New histamine H(3)-receptor ligands of the proxifan series: imoproxifan and other selective antagonists with high oral in vivo potency. J Med Chem 43:3335-43 (2000) [PubMed]  Article 
Target
Name:
Histamine H3 receptor
Synonyms:
HH3R | HRH3_RAT | Hrh3
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
48607.98
Organism:
Rattus norvegicus (rat)
Description:
n/a
Residue:
445
Sequence:
MERAPPDGLMNASGTLAGEAAAAGGARGFSAAWTAVLAALMALLIVATVLGNALVMLAFVADSSLRTQNNFFLLNLAISDFLVGAFCIPLYVPYVLTGRWTFGRGLCKLWLVVDYLLCASSVFNIVLISYDRFLSVTRAVSYRAQQGDTRRAVRKMALVWVLAFLLYGPAILSWEYLSGGSSIPEGHCYAEFFYNWYFLITASTLEFFTPFLSVTFFNLSIYLNIQRRTRLRLDGGREAGPEPPPDAQPSPPPAPPSCWGCWPKGHGEAMPLHRYGVGEAGPGVEAGEAALGGGSGGGAAASPTSSSGSSSRGTERPRSLKRGSKPSASSASLEKRMKMVSQSITQRFRLSRDKKVAKSLAIIVSIFGLCWAPYTLLMIIRAACHGRCIPDYWYETSFWLLWANSAVNPVLYPLCHYSFRRAFTKLLCPQKLKVQPHGSLEQCWK
  
Inhibitor
Name:
BDBM50091373
Synonyms:
1-{2-Fluoro-4-[3-(1H-imidazol-4-yl)-propoxy]-phenyl}-ethanone oxime; compound with but-2-enedioic acid | CHEMBL321835
Type:
Small organic molecule
Emp. Form.:
C14H16FN3O2
Mol. Mass.:
277.2941
SMILES:
CC(N=O)c1ccc(OCCCc2cnc[nH]2)cc1F
Structure:
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