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Target
Adenylate cyclase type 8
Ligand
BDBM50537925
Substrate
n/a
Meas. Tech.
ChEMBL_1970863 (CHEMBL4603681)
EC50
105±n/a nM
Citation
 Weng, Z; Xu, G; Chen, D; Yang, Y; Song, G; Shen, W; Zhang, S; Wang, L; Yang, W; Zuo, Z Discovery of a potent and selective adenylyl cyclase type 8 agonist by docking-based virtual screening. Bioorg Med Chem Lett 30:0 (2020) [PubMed]  Article 
Target
Name:
Adenylate cyclase type 8
Synonyms:
4.6.1.1 | AC8 | ADCY8 | ADCY8_HUMAN | ATP pyrophosphate-lyase 8 | Adenylate cyclase type 8 | Adenylate cyclase type VIII | Adenylyl cyclase 8 | Ca(2+)/calmodulin-activated adenylyl cyclase
Type:
PROTEIN
Mol. Mass.:
140131.08
Organism:
Homo sapiens (Human)
Description:
ChEMBL_104878
Residue:
1251
Sequence:
MELSDVRCLTGSEELYTIHPTPPAGDGRSASRPQRLLWQTAVRHITEQRFIHGHRGGSGSGSGGSGKASDPAGGGPNHHAPQLSGDSALPLYSLGPGERAHSTCGTKVFPERSGSGSASGSGGGGDLGFLHLDCAPSNSDFFLNGGYSYRGVIFPTLRNSFKSRDLERLYQRYFLGQRRKSEVVMNVLDVLTKLTLLVLHLSLASAPMDPLKGILLGFFTGIEVVICALVVVRKDTTSHTYLQYSGVVTWVAMTTQILAAGLGYGLLGDGIGYVLFTLFATYSMLPLPLTWAILAGLGTSLLQVILQVVIPRLAVISINQVVAQAVLFMCMNTAGIFISYLSDRAQRQAFLETRRCVEARLRLETENQRQERLVLSVLPRFVVLEMINDMTNVEDEHLQHQFHRIYIHRYENVSILFADVKGFTNLSTTLSAQELVRMLNELFARFDRLAHEHHCLRIKILGDCYYCVSGLPEPRQDHAHCCVEMGLSMIKTIRYVRSRTKHDVDMRIGIHSGSVLCGVLGLRKWQFDVWSWDVDIANKLESGGIPGRIHISKATLDCLNGDYNVEEGHGKERNEFLRKHNIETYLIKQPEDSLLSLPEDIVKESVSSSDRRNSGATFTEGSWSPELPFDNIVGKQNTLAALTRNSINLLPNHLAQALHVQSGPEEINKRIEHTIDLRSGDKLRREHIKPFSLMFKDSSLEHKYSQMRDEVFKSNLVCAFIVLLFITAIQSLLPSSRVMPMTIQFSILIMLHSALVLITTAEDYKCLPLILRKTCCWINETYLARNVIIFASILINFLGAILNILWCDFDKSIPLKNLTFNSSAVFTDICSYPEYFVFTGVLAMVTCAVFLRLNSVLKLAVLLIMIAIYALLTETVYAGLFLRYDNLNHSGEDFLGTKEVSLLLMAMFLLAVFYHGQQLEYTARLDFLWRVQAKEEINEMKELREHNENMLRNILPSHVARHFLEKDRDNEELYSQSYDAVGVMFASIPGFADFYSQTEMNNQGVECLRLLNEIIADFDELLGEDRFQDIEKIKTIGSTYMAVSGLSPEKQQCEDKWGHLCALADFSLALTESIQEINKHSFNNFELRIGISHGSVVAGVIGAKKPQYDIWGKTVNLASRMDSTGVSGRIQVPEETYLILKDQGFAFDYRGEIYVKGISEQEGKIKTYFLLGRVQPNPFILPPRRLPGQYSLAAVVLGLVQSLNRQRQKQLLNENNNTGIIKGHYNRRTLLSPSGTEPGAQAEGTDKSDLP
  
Inhibitor
Name:
BDBM50537925
Synonyms:
CHEMBL4644318
Type:
Small organic molecule
Emp. Form.:
C18H15Cl2NO3
Mol. Mass.:
364.223
SMILES:
CCOC(=O)C1(Cc2ccc(Cl)cc2Cl)C(=O)Nc2ccccc12
Structure:
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