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Target
Solute carrier family 2, facilitated glucose transporter member 3
Ligand
BDBM50514308
Substrate
n/a
Meas. Tech.
ChEMBL_1972719 (CHEMBL4605537)
IC50
4809±n/a nM
Citation
 Liu, KG; Kim, JI; Olszewski, K; Barsotti, AM; Morris, K; Lamarque, C; Yu, X; Gaffney, J; Feng, XJ; Patel, JP; Poyurovsky, MV Discovery and Optimization of Glucose Uptake Inhibitors. J Med Chem 63:5201-5211 (2020) [PubMed]  Article 
Target
Name:
Solute carrier family 2, facilitated glucose transporter member 3
Synonyms:
GLUT-3 | GLUT3 | GTR3_HUMAN | Glucose transporter type 3, brain | SLC2A3 | Solute carrier family 2, facilitated glucose transporter member 3
Type:
PROTEIN
Mol. Mass.:
53925.15
Organism:
Homo sapiens (Human)
Description:
ChEMBL_101113
Residue:
496
Sequence:
MGTQKVTPALIFAITVATIGSFQFGYNTGVINAPEKIIKEFINKTLTDKGNAPPSEVLLTSLWSLSVAIFSVGGMIGSFSVGLFVNRFGRRNSMLIVNLLAVTGGCFMGLCKVAKSVEMLILGRLVIGLFCGLCTGFVPMYIGEISPTALRGAFGTLNQLGIVVGILVAQIFGLEFILGSEELWPLLLGFTILPAILQSAALPFCPESPRFLLINRKEEENAKQILQRLWGTQDVSQDIQEMKDESARMSQEKQVTVLELFRVSSYRQPIIISIVLQLSQQLSGINAVFYYSTGIFKDAGVQEPIYATIGAGVVNTIFTVVSLFLVERAGRRTLHMIGLGGMAFCSTLMTVSLLLKDNYNGMSFVCIGAILVFVAFFEIGPGPIPWFIVAELFSQGPRPAAMAVAGCSNWTSNFLVGLLFPSAAHYLGAYVFIIFTGFLITFLAFTFFKVPETRGRTFEDITRAFEGQAHGADRSGKDGVMEMNSIEPAKETTTNV
  
Inhibitor
Name:
BDBM50514308
Synonyms:
CHEMBL4448899
Type:
Small organic molecule
Emp. Form.:
C24H16F4N6O2
Mol. Mass.:
496.4165
SMILES:
Cc1c(NC(=O)c2cc(nc3cc(F)ccc23)C(N)=O)c(nn1Cc1ccc(cc1)C#N)C(F)(F)F
Structure:
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