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Target
Chymotrypsin-C
Ligand
BDBM50096724
Substrate
n/a
Meas. Tech.
ChEBML_197812
IC50
300±n/a nM
Citation
 Bennett, JM; Campbell, AD; Campbell, AJ; Carr, MG; Dunsdon, RM; Greening, JR; Hurst, DN; Jennings, NS; Jones, PS; Jordan, S; Kay, PB; O'Brien, MA; King-Underwood, J; Raynham, TM; Wilkinson, CS; Wilkinson, TC; Wilson, FX The identification of alpha-ketoamides as potent inhibitors of hepatitis C virus NS3-4A proteinase. Bioorg Med Chem Lett 11:355-7 (2001) [PubMed]  Article 
Target
Name:
Chymotrypsin-C
Synonyms:
CLCR | CTRC | CTRC_HUMAN | Caldecrin | Chymotrypsin | Chymotrypsin C | Chymotrypsin-C
Type:
Enzyme
Mol. Mass.:
29487.98
Organism:
Homo sapiens (Human)
Description:
Q99895
Residue:
268
Sequence:
MLGITVLAALLACASSCGVPSFPPNLSARVVGGEDARPHSWPWQISLQYLKNDTWRHTCGGTLIASNFVLTAAHCISNTRTYRVAVGKNNLEVEDEEGSLFVGVDTIHVHKRWNALLLRNDIALIKLAEHVELSDTIQVACLPEKDSLLPKDYPCYVTGWGRLWTNGPIADKLQQGLQPVVDHATCSRIDWWGFRVKKTMVCAGGDGVISACNGDSGGPLNCQLENGSWEVFGIVSFGSRRGCNTRKKPVVYTRVSAYIDWINEKMQL
  
Inhibitor
Name:
BDBM50096724
Synonyms:
(S)-4-((S)-1-{(S)-1-[(S)-1-((R)-1-Aminooxalyl-pentylcarbamoyl)-3-methyl-butylcarbamoyl]-2,2-dimethyl-propylcarbamoyl}-2-o-tolyl-ethylcarbamoyl)-4-[(S)-3-carboxy-2-(3-carboxy-propionylamino)-propionylamino]-butyric acid | CHEMBL331243
Type:
Small organic molecule
Emp. Form.:
C42H63N7O14
Mol. Mass.:
889.9881
SMILES:
CCCC[C@@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1C)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CC(O)=O)NC(=O)CCC(O)=O)C(C)(C)C)C(=O)C(N)=O
Structure:
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