Reaction Details Report a problem with these data
Target
Sigma intracellular receptor 2
Ligand
BDBM50540828
Substrate
n/a
Meas. Tech.
ChEMBL_1983061 (CHEMBL4616323)
Ki
3.3±n/a nM
Citation
 Franchini, S; Linciano, P; Puja, G; Tait, A; Borsari, C; Denora, N; Iacobazzi, RM; Brasili, L; Sorbi, C Novel Dithiolane-Based Ligands Combining Sigma and NMDA Receptor Interactions as Potential Neuroprotective Agents. ACS Med Chem Lett 11:1028-1034 (2020) [PubMed]  Article 
Target
Name:
Sigma intracellular receptor 2
Synonyms:
MAC30 | Meningioma-associated protein 30 | S2R | SGMR2_HUMAN | Sigma-2 receptor | Sigma2 receptor | TMEM97 | Transmembrane protein 97
Type:
Protein
Mol. Mass.:
20857.20
Organism:
Homo sapiens (Human)
Description:
Q5BJF2
Residue:
176
Sequence:
MGAPATRRCVEWLLGLYFLSHIPITLFMDLQAVLPRELYPVEFRNLLKWYAKEFKDPLLQEPPAWFKSFLFCELVFQLPFFPIATYAFLKGSCKWIRTPAIIYSVHTMTTLIPILSTFLFEDFSKASGFKGQRPETLHERLTLVSVYAPYLLIPFILLIFMLRSPYYKYEEKRKKK
  
Inhibitor
Name:
BDBM50540828
Synonyms:
CHEMBL4633444
Type:
Small organic molecule
Emp. Form.:
C21H30N2O8S2
Mol. Mass.:
502.602
SMILES:
OC(=O)C(O)=O.OC(=O)C(O)=O.CC1(C)SCC(CN2CCN(Cc3ccccc3)CC2)S1
Structure:
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