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Target
Coagulation factor X
Ligand
BDBM12751
Substrate
n/a
Meas. Tech.
ChEMBL_48951 (CHEMBL661664)
Ki
0.030000±n/a nM
Citation
 Fevig, JM; Pinto, DJ; Han, Q; Quan, ML; Pruitt, JR; Jacobson, IC; Galemmo, RA; Wang, S; Orwat, MJ; Bostrom, LL; Knabb, RM; Wong, PC; Lam PYS, na; Wexler, RR Synthesis and SAR of benzamidine factor Xa inhibitors containing a vicinally-substituted heterocyclic core. Bioorg Med Chem Lett 11:641-5 (2001) [PubMed]  Article 
Target
Name:
Coagulation factor X
Synonyms:
F10 | FA10_RABIT
Type:
PROTEIN
Mol. Mass.:
53951.21
Organism:
Oryctolagus cuniculus
Description:
ChEMBL_1471174
Residue:
490
Sequence:
MANPLHLVLLGAALAGLLLSGSSVFISRRAANDVLARTRRANSFLEELKKGNLERECMEENCSYEEALEVFEDREKTNEFWNKYVDGDQCESNPCQNQGTCKDGLGMYTCSCVEGYEGQDCEPVTRKLCSLDNGGCDQFCKEEENSVLCSCASGYTLGDNGKSCISTELFPCGKVTLGRWRRSPATNSSEGPPEAPGPEQQDDGNLTATENPFNLLDSPEPPPEDDSSSLVRIVGGQDCRDGECPWQALLVNEENEGFCGGTILSEYHVLTAAHCLHQAKRFKVRVGDRDTEHEEGNEETHEVEVVVKHNRFVKETYDFDIAVLRLKTPITFRRNVAPACLPQKDWAESTLMAQKTGIVSGFGRTHEMGRLSTTLKMLEVPYVDRNSCKRSSSFTITQNMFCAGYDARPEDACQGDSGGPHVTRFRDTYFVTGIVSWGEGCARKGKFGVYTKVSNFLKWIEKSMRARAVPVAEAAGTPGPTQPTIKGSPS
  
Inhibitor
Name:
BDBM12751
Synonyms:
1-(3-carbamimidoylphenyl)-3-methyl-N-[4-(2-sulfamoylphenyl)phenyl]-1H-pyrazole-5-carboxamide | CHEMBL152854 | CHEMBL37251 | SN-429
Type:
Small organic molecule
Emp. Form.:
C24H22N6O3S
Mol. Mass.:
474.535
SMILES:
Cc1cc(C(=O)Nc2ccc(cc2)-c2ccccc2S(N)(=O)=O)n(n1)-c1cccc(c1)C(N)=N
Structure:
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